In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) that line joint synovial membranes aggressively invade the extracellular matrix, destroying cartilage and bone. As signal transduction in FLS is mediated through multiple pathways involving protein tyrosine phosphorylation, we sought to identify protein tyrosine phosphatases (PTPs) regulating the invasiveness of RA FLS. We describe that the transmembrane receptor PTPκ (RPTPκ), encoded by the transforming growth factor (TGF) β-target gene, PTPRK, promotes RA FLS invasiveness.
Stanford, S., Aleman Muench, G., Bartok, B., Sacchetti, C., Kiosses, W., Sharma, J., et al. (2014). TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness. ANNALS OF THE RHEUMATIC DISEASES [10.1136/annrheumdis-2014-205790].
TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness
BOTTINI, MASSIMO;
2014-11-06
Abstract
In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) that line joint synovial membranes aggressively invade the extracellular matrix, destroying cartilage and bone. As signal transduction in FLS is mediated through multiple pathways involving protein tyrosine phosphorylation, we sought to identify protein tyrosine phosphatases (PTPs) regulating the invasiveness of RA FLS. We describe that the transmembrane receptor PTPκ (RPTPκ), encoded by the transforming growth factor (TGF) β-target gene, PTPRK, promotes RA FLS invasiveness.| File | Dimensione | Formato | |
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Ann Rheum Dis 2014 VQR Bottini 5.pdf
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PMID 25378349 - Ann Rheum Dis.pdf
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