Human immunodeficiency virus (HIV) disease progression depends on several host factors. Among them human leukocyte antigen (HLA) locus has a main role due to the peculiar capability to modulate both innate and adaptive immune response. In this review, the role of HLA molecules and its receptors in HIV progression toward acquired immunodeficiency disease syndrome is summarized. A better knowledge about HLA-peptide presentation and recognition by immune cells will open new applications in HIV vaccine and diagnostics design.
Grifoni, A., Montesano, C., Colizzi, V., Amicosante, M. (2015). Key role of human leukocyte antigen in modulating HIV progression: an overview of the possible applications. WORLD JOURNAL OF VIROLOGY, 4(2), 124-133 [http://dx.doi.org/10.5501/wjv.v4.i2.124].
Key role of human leukocyte antigen in modulating HIV progression: an overview of the possible applications.
MONTESANO, CARLA;COLIZZI, VITTORIO;AMICOSANTE, MASSIMO
2015-05-01
Abstract
Human immunodeficiency virus (HIV) disease progression depends on several host factors. Among them human leukocyte antigen (HLA) locus has a main role due to the peculiar capability to modulate both innate and adaptive immune response. In this review, the role of HLA molecules and its receptors in HIV progression toward acquired immunodeficiency disease syndrome is summarized. A better knowledge about HLA-peptide presentation and recognition by immune cells will open new applications in HIV vaccine and diagnostics design.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
