Low-grade inflammation is a common feature of chronic kidney disease (CKD) and persistent systemic inflammation is thought to be a strong predictor of cardiovascular events. Inflammation plays a role in determining the serum albumin levels in haemodialysis patients (HD) independently of the nutritional status. Increased cardiovascular mortality in CKD has been associated with the increased incidence of obesity in uremic patients. Ingenbleek suggested a prognostic inflammation and nutritional index (PINI), based on serum albumin, pre-albumin, C-reactive protein, and alpha1 acid glycoprotein, to identify and to follow up acutely ill patients at risk of major complications. The aims of the present study were: to verify the incidence of Normal Weight Obese (NWO) syndrome; to evaluate by PINI the effect of 8 weeks acetyl salicylic (100 mg/die) and atorvastatin (10 mg/die) combined treatment on chronic inflammation in 52 selected HD patients. Laboratory evaluation, anthropometric and body composition measurements were detected. At baseline the 56.25% of non-obese, the 84.21% of pre-obese-obese, and the 41.17% of NWO women showed PINI values >1 (normal status PINI<1). After the pharmacological treatment, high significant (P<0.001) reduction in lipid profile, an elevated increase of HDL levels, and a significant reduction of inflammatory markers were obtained. Firstly, our results showed that ASA and atorvastatin combined treatment was effective in reducing inflammatory status in HD patients independently of body composition: at the end of the study only 7.49% of the patients exhibited PINI>1. Further studies will be necessary to understand the causes of inflammation in non-responder patients.

DI RENZO, L., Noce, A., De Angelis, S., Miani, N., DI DANIELE, N., Tozzo, C., et al. (2008). The evaluation of breast tissues removed during reductive mammaplasty with dual energy X-ray absorptiometry. PHARMACOLOGICAL RESEARCH, 57(2), 93-99 [10.1016/j.phrs.2007.11.005].

The evaluation of breast tissues removed during reductive mammaplasty with dual energy X-ray absorptiometry

DI RENZO, LAURA;Noce, A;DI DANIELE, NICOLA;TOZZO, CARMELA;DE LORENZO, ANTONINO
2008-02-01

Abstract

Low-grade inflammation is a common feature of chronic kidney disease (CKD) and persistent systemic inflammation is thought to be a strong predictor of cardiovascular events. Inflammation plays a role in determining the serum albumin levels in haemodialysis patients (HD) independently of the nutritional status. Increased cardiovascular mortality in CKD has been associated with the increased incidence of obesity in uremic patients. Ingenbleek suggested a prognostic inflammation and nutritional index (PINI), based on serum albumin, pre-albumin, C-reactive protein, and alpha1 acid glycoprotein, to identify and to follow up acutely ill patients at risk of major complications. The aims of the present study were: to verify the incidence of Normal Weight Obese (NWO) syndrome; to evaluate by PINI the effect of 8 weeks acetyl salicylic (100 mg/die) and atorvastatin (10 mg/die) combined treatment on chronic inflammation in 52 selected HD patients. Laboratory evaluation, anthropometric and body composition measurements were detected. At baseline the 56.25% of non-obese, the 84.21% of pre-obese-obese, and the 41.17% of NWO women showed PINI values >1 (normal status PINI<1). After the pharmacological treatment, high significant (P<0.001) reduction in lipid profile, an elevated increase of HDL levels, and a significant reduction of inflammatory markers were obtained. Firstly, our results showed that ASA and atorvastatin combined treatment was effective in reducing inflammatory status in HD patients independently of body composition: at the end of the study only 7.49% of the patients exhibited PINI>1. Further studies will be necessary to understand the causes of inflammation in non-responder patients.
feb-2008
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
English
Syndrome; Middle Aged; Serum Albumin; Drug Therapy, Combination; Body Fat Distribution; Cholesterol, HDL; Inflammation; Obesity; Lipid Metabolism; Renal Dialysis; Aged; Adult; Prealbumin; Heptanoic Acids; Male; Anticholesteremic Agents; Female; Kidney Failure, Chronic; Nutrition Assessment; Cardiovascular Diseases; Body Weight; Anti-Inflammatory Agents, Non-Steroidal; Humans; Body Mass Index; Aspirin; Pyrroles; C-Reactive Protein
DI RENZO, L., Noce, A., De Angelis, S., Miani, N., DI DANIELE, N., Tozzo, C., et al. (2008). The evaluation of breast tissues removed during reductive mammaplasty with dual energy X-ray absorptiometry. PHARMACOLOGICAL RESEARCH, 57(2), 93-99 [10.1016/j.phrs.2007.11.005].
DI RENZO, L; Noce, A; De Angelis, S; Miani, N; DI DANIELE, N; Tozzo, C; DE LORENZO, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/11054
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