The neuroactive steroids allopregnanolone (ALLO) and allotet-rahydrodeoxycorticosterone (THDOC) are the most potent endogens positive modulators of gamma-aminobutyric acid (GABA) on GABAA receptors, a receptor system presumably responsible for some behavioral responses to alcohol withdrawal. In a group of nine alcoholic subjects, the levels of plasma ALLO and THDOC were markedly lower than those of control subjects during the early withdrawal phase (day 4 and 5), when anxiety and depression scores were higher. In contrast ALLO and THDOC plasma levels did not differ from those of control subjects during the late withdrawal phase when anxiety and depression scores were low. These results suggest that the decrease of neuroactive steroid biosynthesis may contribute to the withdrawal symptoms.

Romeo, E., Brancati, A., DE LORENZO, A., Fucci, P., Furnari, C., Pompili, E., et al. (1996). Marked decrease of plasma neuroactive steroids during alcohol withdrawal. CLINICAL NEUROPHARMACOLOGY, 19(4), 366-9.

Marked decrease of plasma neuroactive steroids during alcohol withdrawal

BRANCATI, ALDO;DE LORENZO, ANTONINO;FUCCI, PIERO;FURNARI, CARMELO;TROISI, ALFONSO;PASINI, AUGUSTO
1996

Abstract

The neuroactive steroids allopregnanolone (ALLO) and allotet-rahydrodeoxycorticosterone (THDOC) are the most potent endogens positive modulators of gamma-aminobutyric acid (GABA) on GABAA receptors, a receptor system presumably responsible for some behavioral responses to alcohol withdrawal. In a group of nine alcoholic subjects, the levels of plasma ALLO and THDOC were markedly lower than those of control subjects during the early withdrawal phase (day 4 and 5), when anxiety and depression scores were higher. In contrast ALLO and THDOC plasma levels did not differ from those of control subjects during the late withdrawal phase when anxiety and depression scores were low. These results suggest that the decrease of neuroactive steroid biosynthesis may contribute to the withdrawal symptoms.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
English
Male; Middle Aged; Anxiety; Substance Withdrawal Syndrome; Adult; Steroids; Ethanol; Humans
Romeo, E., Brancati, A., DE LORENZO, A., Fucci, P., Furnari, C., Pompili, E., et al. (1996). Marked decrease of plasma neuroactive steroids during alcohol withdrawal. CLINICAL NEUROPHARMACOLOGY, 19(4), 366-9.
Romeo, E; Brancati, A; DE LORENZO, A; Fucci, P; Furnari, C; Pompili, E; Sasso, G; Spalletta, G; Troisi, A; Pasini, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/11043
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