This report describes a unique case of acute promyelocytic leukemia (APL) showing elusive morphologic features, an atypical pattern of cytochemical reactions, and a previously unreported immunophenotype consistent with a very early myeloid form: CD13 (+), CD33 (+), CD9 (+), CD2 (+), HLA-DR (-), CD34 (+), CD117 (+), and TdT (+). The diagnosis of AML M3 variant was made only after genotypic analyses revealed the PML/RARx rearrangement associated with the typical (15;17) (q22;q21) translocation. This example of 'asynchronous differentiation' emphasizes the need for a multiparameter approach to the diagnosis of acute leukemia.

Stasi, R., Bruno, A., Venditti, A., DEL POETA, G., Aronica, G., Cox, M., et al. (1997). A microgranular variant of acute promyelocytic leukemia with atypical morpho-cytochemical features and an early myeloid immunophenotype. LEUKEMIA RESEARCH, 21(6), 575-580 [10.1016/S0145-2126(97)00094-5].

A microgranular variant of acute promyelocytic leukemia with atypical morpho-cytochemical features and an early myeloid immunophenotype

BRUNO, ANTONIO;VENDITTI, ADRIANO;DEL POETA, GIOVANNI;CATALANO, GIANFRANCO;ZANGRILLI, DANIELA;AMADORI, SERGIO
1997

Abstract

This report describes a unique case of acute promyelocytic leukemia (APL) showing elusive morphologic features, an atypical pattern of cytochemical reactions, and a previously unreported immunophenotype consistent with a very early myeloid form: CD13 (+), CD33 (+), CD9 (+), CD2 (+), HLA-DR (-), CD34 (+), CD117 (+), and TdT (+). The diagnosis of AML M3 variant was made only after genotypic analyses revealed the PML/RARx rearrangement associated with the typical (15;17) (q22;q21) translocation. This example of 'asynchronous differentiation' emphasizes the need for a multiparameter approach to the diagnosis of acute leukemia.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - Malattie del Sangue
English
Con Impact Factor ISI
Stasi, R., Bruno, A., Venditti, A., DEL POETA, G., Aronica, G., Cox, M., et al. (1997). A microgranular variant of acute promyelocytic leukemia with atypical morpho-cytochemical features and an early myeloid immunophenotype. LEUKEMIA RESEARCH, 21(6), 575-580 [10.1016/S0145-2126(97)00094-5].
Stasi, R; Bruno, A; Venditti, A; DEL POETA, G; Aronica, G; Cox, M; Maffei, L; Catalano, G; Zangrilli, D; Amadori, S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/110300
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