Insulin resistance and obesity are intimately related to a chronic low grade systemic inflammation. Interleukin-6 (IL-6) may influence the pathogenesis of obesity-related diseases. The aim of this study is to investigate the effect of body's fat mass on the relationships between -174G/C IL-6 promoter gene polymorphism, IL-6 circulating level and insulin resistance. A population of 150 Caucasian women was studied, subdivided according to their body composition in non-obese (NW), Normal Weight Obese (NWO) and preobese-obese (OB). The NWO subjects were found in an intermediate position between the NW and OB subjects in terms of body weight, fat mass percentage (FM%), abdominal FAT%, hs-CRP and plasma triglyceride level. Fasting plasma IL-6 concentration was positively correlated with the homeostasis model assessment for insulin resistance (HOMA-IR) in all subjects analyzed (P=0.0014). In NWO and OB women a significantly increased IL-6 mean value was observed compared with NW subjects. In G/G population, the IL-6 plasma level of NWO and OB was significantly higher with respect to NW. No significant differences of IL-6 concentrations were observed in the three groups carrying G/C genotype. NWO and OB women homozygous for the allele C have significantly lower value of IL-6 with respect to NW subjects. IL-6 concentration was positively correlated with FM% in G/G (R(2)=0.397, P<0.001) and was negatively correlated in C/C (R(2)=0.459, P=0.002). No significant correlation was observed in G/C genotype (R(2)=0.041, P=0.173). In conclusion our study confirms that, at least in Italian Caucasian females, the FM% is a major determinant of an increase in IL-6 production and insulin resistance. -174 G/C IL-6 promoter polymorphism represents a marker which could help to identify, time in advance, "vulnerable" individuals at risk of age and obesity related diseases.

DI RENZO, L., Bertoli, A., Bigioni, M., DEL GOBBO, V., PREMROV CARBUCICCHIO, M.g., Calabrese, V., et al. (2008). Body composition and -174G/C interleukin-6 promoter gene polymorphism: association with progression of insulin resistance in normal weight obese syndrome. CURRENT PHARMACEUTICAL DESIGN, 14(26), 2699-2706 [10.2174/138161208786264061].

Body composition and -174G/C interleukin-6 promoter gene polymorphism: association with progression of insulin resistance in normal weight obese syndrome

DI RENZO, LAURA;BERTOLI, ALDO;DEL GOBBO, VERA;PREMROV CARBUCICCHIO, MARIA GRAZIA;DI DANIELE, NICOLA;DE LORENZO, ANTONINO
2008-01-01

Abstract

Insulin resistance and obesity are intimately related to a chronic low grade systemic inflammation. Interleukin-6 (IL-6) may influence the pathogenesis of obesity-related diseases. The aim of this study is to investigate the effect of body's fat mass on the relationships between -174G/C IL-6 promoter gene polymorphism, IL-6 circulating level and insulin resistance. A population of 150 Caucasian women was studied, subdivided according to their body composition in non-obese (NW), Normal Weight Obese (NWO) and preobese-obese (OB). The NWO subjects were found in an intermediate position between the NW and OB subjects in terms of body weight, fat mass percentage (FM%), abdominal FAT%, hs-CRP and plasma triglyceride level. Fasting plasma IL-6 concentration was positively correlated with the homeostasis model assessment for insulin resistance (HOMA-IR) in all subjects analyzed (P=0.0014). In NWO and OB women a significantly increased IL-6 mean value was observed compared with NW subjects. In G/G population, the IL-6 plasma level of NWO and OB was significantly higher with respect to NW. No significant differences of IL-6 concentrations were observed in the three groups carrying G/C genotype. NWO and OB women homozygous for the allele C have significantly lower value of IL-6 with respect to NW subjects. IL-6 concentration was positively correlated with FM% in G/G (R(2)=0.397, P<0.001) and was negatively correlated in C/C (R(2)=0.459, P=0.002). No significant correlation was observed in G/C genotype (R(2)=0.041, P=0.173). In conclusion our study confirms that, at least in Italian Caucasian females, the FM% is a major determinant of an increase in IL-6 production and insulin resistance. -174 G/C IL-6 promoter polymorphism represents a marker which could help to identify, time in advance, "vulnerable" individuals at risk of age and obesity related diseases.
2008
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
Settore MED/09 - MEDICINA INTERNA
English
European Continental Ancestry Group; Retrospective Studies; Syndrome; Young Adult; Middle Aged; Female; Italy; Insulin Resistance; Body Weight; Body Fat Distribution; Humans; Triglycerides; Polymorphism, Genetic; Obesity; Body Mass Index; Disease Progression; Homeostasis; Promoter Regions, Genetic; Adult; Interleukin-6; C-Reactive Protein
DI RENZO, L., Bertoli, A., Bigioni, M., DEL GOBBO, V., PREMROV CARBUCICCHIO, M.g., Calabrese, V., et al. (2008). Body composition and -174G/C interleukin-6 promoter gene polymorphism: association with progression of insulin resistance in normal weight obese syndrome. CURRENT PHARMACEUTICAL DESIGN, 14(26), 2699-2706 [10.2174/138161208786264061].
DI RENZO, L; Bertoli, A; Bigioni, M; DEL GOBBO, V; PREMROV CARBUCICCHIO, Mg; Calabrese, V; DI DANIELE, N; DE LORENZO, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/11025
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