We report a case of drug-induced Kaposi's sarcoma (KS) on the sole of the right foot in a 71-year-old man, treated for 6 months with corticosteroid therapy (prednisolone 25 mg/day) for pericardial effusion. After corticosteroid withdrawal, a tuberculin skin test became strongly positive and pericardial effusion was considered to be of tubercular origin. The patient remained constantly HIV negative during 14 months of follow-up. Seven months after continuous antitubercular treatment, the KS nodules regressed spontaneously and finally disappeared. Histological studies confirmed the diagnosis of KS and documented its complete regression. Laboratory investigation confirmed prior exposure to CMV, EBV and HSV and suggested drug-induced immunological suppression. Analysis of the HLA system revealed the positivity of locus DR5, associated with classical KS. This case report underscores the relationship between genetic background, environmental factors, drug-induced immunosuppression and the evolution of this peculiar neoplasm.

Sangiorgi, G., Orlandi, A., DE NARDO, D., Sangiorgi, M., Spagnoli, L. (1993). Complete regression of iatrogenic Kaposi's sarcoma due to corticosteroid treatment in a patient with tubercular pericarditis. A case report. ANNALI ITALIANI DI MEDICINA INTERNA, 8(1), 21-24.

Complete regression of iatrogenic Kaposi's sarcoma due to corticosteroid treatment in a patient with tubercular pericarditis. A case report

SANGIORGI, GIUSEPPE;ORLANDI, AUGUSTO;DE NARDO, DOMENICO;
1993-01-01

Abstract

We report a case of drug-induced Kaposi's sarcoma (KS) on the sole of the right foot in a 71-year-old man, treated for 6 months with corticosteroid therapy (prednisolone 25 mg/day) for pericardial effusion. After corticosteroid withdrawal, a tuberculin skin test became strongly positive and pericardial effusion was considered to be of tubercular origin. The patient remained constantly HIV negative during 14 months of follow-up. Seven months after continuous antitubercular treatment, the KS nodules regressed spontaneously and finally disappeared. Histological studies confirmed the diagnosis of KS and documented its complete regression. Laboratory investigation confirmed prior exposure to CMV, EBV and HSV and suggested drug-induced immunological suppression. Analysis of the HLA system revealed the positivity of locus DR5, associated with classical KS. This case report underscores the relationship between genetic background, environmental factors, drug-induced immunosuppression and the evolution of this peculiar neoplasm.
1993
Pubblicato
Rilevanza nazionale
Articolo
Esperti anonimi
Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE
English
Con Impact Factor ISI
Neoplasm Regression, Spontaneous; Skin; Iatrogenic Disease; Humans; Sarcoma, Kaposi; Aged; Biopsy; Pericardial Effusion; Skin Neoplasms; Foot Diseases; Drug Therapy, Combination; Pericarditis, Tuberculous; HIV Seropositivity; Prednisolone; Antitubercular Agents; Time Factors; Male
Sangiorgi, G., Orlandi, A., DE NARDO, D., Sangiorgi, M., Spagnoli, L. (1993). Complete regression of iatrogenic Kaposi's sarcoma due to corticosteroid treatment in a patient with tubercular pericarditis. A case report. ANNALI ITALIANI DI MEDICINA INTERNA, 8(1), 21-24.
Sangiorgi, G; Orlandi, A; DE NARDO, D; Sangiorgi, M; Spagnoli, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/108175
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