Intestinal function in children with very short bowel syndrome and related intestinal failure may improve after isolated liver transplantation. An infant with an ultrashort gut, ileo-cecal valve, and whole colon received total parenteral nutrition from the first days of life. Enteral feeding failed because of the progressive dilatation of the jejunal portion and motility disorders. He developed early severe cholestatic liver disease (aspartate transferase 186, alanine transferase 103 U/L, serum bilirubin 8.4 mg/dL) and subsequent liver failure. At 8 months of age, he benefited from isolated liver transplantation (left segment graft from living donor). His early posttransplant evolution was characterized by recovery of oral alimentation, improvement of digestive and absorption functions, but he did not achieve TPN-independence. At 20 months, 50% to 60% of his energy needs were covered by parenteral nutrition and he has satisfactory growth indices (3rd percentile for weight and height), reduced stool volume, and frequency. Isolated liver transplantation allowed, in this particular case, time for further intestinal adaptation thereby avoiding the need for intestinal transplantation early in life.

Lezo, A., Gennari, F., Santini, B., Calvo, P., Baldi, M., Salizzoni, M., et al. (2006). Isolated liver transplantation in an infant with ultrashort gut. TRANSPLANTATION PROCEEDINGS, 38(6), 1713-1715 [10.1016/j.transproceed.2006.05.045].

Isolated liver transplantation in an infant with ultrashort gut

DE VILLE DE GOYET, JEAN
2006-01-01

Abstract

Intestinal function in children with very short bowel syndrome and related intestinal failure may improve after isolated liver transplantation. An infant with an ultrashort gut, ileo-cecal valve, and whole colon received total parenteral nutrition from the first days of life. Enteral feeding failed because of the progressive dilatation of the jejunal portion and motility disorders. He developed early severe cholestatic liver disease (aspartate transferase 186, alanine transferase 103 U/L, serum bilirubin 8.4 mg/dL) and subsequent liver failure. At 8 months of age, he benefited from isolated liver transplantation (left segment graft from living donor). His early posttransplant evolution was characterized by recovery of oral alimentation, improvement of digestive and absorption functions, but he did not achieve TPN-independence. At 20 months, 50% to 60% of his energy needs were covered by parenteral nutrition and he has satisfactory growth indices (3rd percentile for weight and height), reduced stool volume, and frequency. Isolated liver transplantation allowed, in this particular case, time for further intestinal adaptation thereby avoiding the need for intestinal transplantation early in life.
2006
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/20 - CHIRURGIA PEDIATRICA E INFANTILE
English
Digestion; Parenteral Nutrition, Total; Humans; Treatment Outcome; Intestine, Small; Infant, Newborn; Short Bowel Syndrome; Nutritional Physiological Phenomena; Male; Liver Transplantation
Lezo, A., Gennari, F., Santini, B., Calvo, P., Baldi, M., Salizzoni, M., et al. (2006). Isolated liver transplantation in an infant with ultrashort gut. TRANSPLANTATION PROCEEDINGS, 38(6), 1713-1715 [10.1016/j.transproceed.2006.05.045].
Lezo, A; Gennari, F; Santini, B; Calvo, P; Baldi, M; Salizzoni, M; Barbera, C; Otte, J; DE VILLE DE GOYET, J
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/108130
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