Deficits in processing contextual information are one of the main features of cognitive dysfunction in schizophrenia, but the neurophysiologic substrate underlying this dysfunction is poorly understood. We used ERPs to investigate local contextual processing in schizophrenic patients. Local context was defined as the occurrence of a short predictive series of stimuli occurring before delivery of a target event. Response times of predicted targets were faster in controls compared to patients. Schizophrenia patients failed to generate the P3b latency shift between predicted and random targets that was observed in controls and demonstrated a prominent reduction of the peak of an early latency context dependent positivity. The current study provides evidence of contextual processing deficits in schizophrenia patients by demonstrating alteration in the behavioral and neural correlates of local contextual processing.

Fogelson, N., Ribolsi, M., Fernandez-Del-Olmo, M., Rubino, I., Romeo, D., Koch, G., et al. (2011). Neural correlates of local contextual processing deficits in schizophrenic patients. PSYCHOPHYSIOLOGY, 48(9), 1217-1226 [10.1111/j.1469-8986.2011.01195.x].

Neural correlates of local contextual processing deficits in schizophrenic patients

RIBOLSI, MICHELE;RUBINO, IVO;
2011-09

Abstract

Deficits in processing contextual information are one of the main features of cognitive dysfunction in schizophrenia, but the neurophysiologic substrate underlying this dysfunction is poorly understood. We used ERPs to investigate local contextual processing in schizophrenic patients. Local context was defined as the occurrence of a short predictive series of stimuli occurring before delivery of a target event. Response times of predicted targets were faster in controls compared to patients. Schizophrenia patients failed to generate the P3b latency shift between predicted and random targets that was observed in controls and demonstrated a prominent reduction of the peak of an early latency context dependent positivity. The current study provides evidence of contextual processing deficits in schizophrenia patients by demonstrating alteration in the behavioral and neural correlates of local contextual processing.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/25 - Psichiatria
eng
Schizophrenia; Cerebral Cortex; Photic Stimulation; Brain Mapping; Evoked Potentials, Visual; Humans; Electroencephalography; Adult; Visual Perception; Male; Female; Reaction Time
Fogelson, N., Ribolsi, M., Fernandez-Del-Olmo, M., Rubino, I., Romeo, D., Koch, G., et al. (2011). Neural correlates of local contextual processing deficits in schizophrenic patients. PSYCHOPHYSIOLOGY, 48(9), 1217-1226 [10.1111/j.1469-8986.2011.01195.x].
Fogelson, N; Ribolsi, M; Fernandez Del Olmo, M; Rubino, I; Romeo, D; Koch, G; Peled, A
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/107739
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact