Berylliosis is an environmental chronic inflammatory disorder of the lung caused by inhalation of insoluble beryllium (Be) dusts and characterized by the accumulation of CD4+ T cells and macrophages in the lower respiratory tract. In response to Be inhalation, noncaseating granuloma formation and, eventually, fibrosis. The immunopathogenic process is maintained by Be-specific lung CD4+ T-lymphocytes. Consistent with the disease immunopathology, these Be-specific T cells have a T-helper 1 phenotype producing interleukin-2 and interferon-gamma, the macrophage-activating cytokine driving the granulomatous reaction. Previous studies have demonstrated that the glutamic acid in position 69 of the human leukocyte antigen class II b chain is strongly associated with increased susceptibility to Be in exposed workers, suggesting that human leukocyte antigen gene markers may be used as epidemiological probes to identify population groups at higher risk.

Saltini, C., Amicosante, M. (2001). Beryllium disease, 321(1), 89-98.

Beryllium disease

SALTINI, CESARE;AMICOSANTE, MASSIMO
2001-01-01

Abstract

Berylliosis is an environmental chronic inflammatory disorder of the lung caused by inhalation of insoluble beryllium (Be) dusts and characterized by the accumulation of CD4+ T cells and macrophages in the lower respiratory tract. In response to Be inhalation, noncaseating granuloma formation and, eventually, fibrosis. The immunopathogenic process is maintained by Be-specific lung CD4+ T-lymphocytes. Consistent with the disease immunopathology, these Be-specific T cells have a T-helper 1 phenotype producing interleukin-2 and interferon-gamma, the macrophage-activating cytokine driving the granulomatous reaction. Previous studies have demonstrated that the glutamic acid in position 69 of the human leukocyte antigen class II b chain is strongly associated with increased susceptibility to Be in exposed workers, suggesting that human leukocyte antigen gene markers may be used as epidemiological probes to identify population groups at higher risk.
gen-2001
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/04 - PATOLOGIA GENERALE
Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO
Settore MED/44 - MEDICINA DEL LAVORO
English
Con Impact Factor ISI
Berylliosis; Macrophages; Diagnosis, Differential; Humans; Amino Acid Sequence; Sarcoidosis; CD4-Positive T-Lymphocytes; HLA-DP Antigens; HLA-DR Antigens; Lung; Beryllium; Molecular Sequence Data; Major Histocompatibility Complex
Saltini, C., Amicosante, M. (2001). Beryllium disease, 321(1), 89-98.
Saltini, C; Amicosante, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/107092
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