Susceptibility to beryllium (Be)-hypersensitivity (BH) has been associated with HLA-DP alleles carrying a glutamate at position 69 of the HLA-DP beta-chain (HLA-DPGlu69) and with several HLA-DP, -DQ and -DR alleles and polymorphisms. However, no genetic associations have been found between BH affected subjects not carrying the HLA-DPGlu69 susceptibility marker.

Amicosante, M., Berretta, F., Rossman, M., Butler, R., Rogliani, P., van den Berg Loonen, E., et al. (2005). Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. RESPIRATORY RESEARCH, 6, 94-94 [10.1186/1465-9921-6-94].

Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69

AMICOSANTE, MASSIMO;ROGLIANI, PAOLA;SALTINI, CESARE
2005-01-01

Abstract

Susceptibility to beryllium (Be)-hypersensitivity (BH) has been associated with HLA-DP alleles carrying a glutamate at position 69 of the HLA-DP beta-chain (HLA-DPGlu69) and with several HLA-DP, -DQ and -DR alleles and polymorphisms. However, no genetic associations have been found between BH affected subjects not carrying the HLA-DPGlu69 susceptibility marker.
2005
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/04 - PATOLOGIA GENERALE
Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO
Settore MED/44 - MEDICINA DEL LAVORO
English
Con Impact Factor ISI
United States; Berylliosis; Polymorphism, Single Nucleotide; DNA Mutational Analysis; Humans; Genetic Markers; Risk Assessment; HLA-DR Antigens; Risk Factors; Alveolitis, Extrinsic Allergic; Beryllium; Adult; Incidence; Genetic Predisposition to Disease; Female; Male
Amicosante, M., Berretta, F., Rossman, M., Butler, R., Rogliani, P., van den Berg Loonen, E., et al. (2005). Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. RESPIRATORY RESEARCH, 6, 94-94 [10.1186/1465-9921-6-94].
Amicosante, M; Berretta, F; Rossman, M; Butler, R; Rogliani, P; van den Berg Loonen, E; Saltini, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/107081
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