Exposure to beryllium (Be) compounds may cause sensitization as revealed by blood T-cell proliferation against Be in a standardized Be-stimulated T-cell proliferation test (BeLPT). Further, susceptibility to Be hypersensitivity has been associated with the expression of HLA-DP allelic variants carrying a glutamate residue at position 69 of the beta-chain (HLA-DPGlu69) in more than 80% of affected subjects and, at lower frequency, with other HLA-DP, -DQ and -DR alleles/polymorphisms. The aim of this study was to assess whether heterozygous or homozygous carriage of the HLA-DPGlu69 marker may dictate the intensity of the T-cell response to Be in vitro.

Amicosante, M., Deubner, D., Saltini, C. (2005). Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test. SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 22(3), 175-179.

Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test

AMICOSANTE, MASSIMO;SALTINI, CESARE
2005-10-01

Abstract

Exposure to beryllium (Be) compounds may cause sensitization as revealed by blood T-cell proliferation against Be in a standardized Be-stimulated T-cell proliferation test (BeLPT). Further, susceptibility to Be hypersensitivity has been associated with the expression of HLA-DP allelic variants carrying a glutamate residue at position 69 of the beta-chain (HLA-DPGlu69) in more than 80% of affected subjects and, at lower frequency, with other HLA-DP, -DQ and -DR alleles/polymorphisms. The aim of this study was to assess whether heterozygous or homozygous carriage of the HLA-DPGlu69 marker may dictate the intensity of the T-cell response to Be in vitro.
ott-2005
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/04 - PATOLOGIA GENERALE
Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO
Settore MED/44 - MEDICINA DEL LAVORO
English
Con Impact Factor ISI
Lymphocyte Activation; Berylliosis; Genetic Variation; HLA-DP Antigens; Humans; Glutamic Acid; Beryllium; Adult; Male; Female; T-Lymphocytes
Amicosante, M., Deubner, D., Saltini, C. (2005). Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test. SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 22(3), 175-179.
Amicosante, M; Deubner, D; Saltini, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/107076
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