Induction of tolerance to insulin is achievable in animal models of Type I (insulin-dependent) Diabetes mellitus by oral treatment with this hormone, which can lead to prevention of the disease. In the Diabetes Prevention Trial of Type I diabetes (DPT-1), oral insulin is given with the aim of preventing disease insurgence. We investigated whether if given at diagnosis of Type I diabetes in humans, oral insulin can still act as a tolerogen and therefore preserve residual beta-cell function, which is known to be substantial at diagnosis.

Pozzilli, P., Pitocco, D., Visalli, N., Cavallo, M., Buzzetti, R., Crinò, A., et al. (2000). No effect of oral insulin on residual beta-cell function in recent-onset type I diabetes (the IMDIAB VII). IMDIAB Group. DIABETOLOGIA, 43(8), 1000-1004.

No effect of oral insulin on residual beta-cell function in recent-onset type I diabetes (the IMDIAB VII). IMDIAB Group

POZZILLI, PAOLO;MANCA BITTI, MARIA LUISA;
2000-08-01

Abstract

Induction of tolerance to insulin is achievable in animal models of Type I (insulin-dependent) Diabetes mellitus by oral treatment with this hormone, which can lead to prevention of the disease. In the Diabetes Prevention Trial of Type I diabetes (DPT-1), oral insulin is given with the aim of preventing disease insurgence. We investigated whether if given at diagnosis of Type I diabetes in humans, oral insulin can still act as a tolerogen and therefore preserve residual beta-cell function, which is known to be substantial at diagnosis.
ago-2000
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
English
Con Impact Factor ISI
Administration, Oral; C-Peptide; Hemoglobin A, Glycosylated; Age of Onset; Double-Blind Method; Humans; Islets of Langerhans; Child; Italy; Insulin; Blood Glucose; Diabetes Mellitus, Type 1; Adult; Injections, Subcutaneous; Adolescent; Male; Female
Pozzilli, P., Pitocco, D., Visalli, N., Cavallo, M., Buzzetti, R., Crinò, A., et al. (2000). No effect of oral insulin on residual beta-cell function in recent-onset type I diabetes (the IMDIAB VII). IMDIAB Group. DIABETOLOGIA, 43(8), 1000-1004.
Pozzilli, P; Pitocco, D; Visalli, N; Cavallo, M; Buzzetti, R; Crinò, A; Spera, S; Suraci, C; Multari, G; Cervoni, M; MANCA BITTI, Ml; Matteoli, M; Ma...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/106914
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