It has been twenty years since the first paper reporting the association between thyroid antibodies (TAIs) and spontaneous miscarriage was published. Following this observation, several studies have clearly demonstrated an increased prevalence of TAI in patients with recurrent miscarriage (RM). However, the exact mechanism underlying this association remains a matter of debate. The aim of the present study was to evaluate the thyroid function, throughout a specific test, in patient with RM and TAI focusing on the hypothesis that TAI should be an indirect sign of a mild thyroid dysfunction. 46 patients with RMand TAI were included in the study. All patients underwent short TRH stimulation test showing an abnormal response in the vast majority of cases (65%). Normal FT4 and FT3 mean values were found whereas TSH values were in the upper normal range (2.64 ± 1.3mUI/L). Our data support the hypothesis that in patients with RM the presence of TAI is an indirect sign of a subtle thyroid dysfunction detectable by a specific test. This test give the possibility to identify women with RM in which specific therapeutic approaches could effectively improve the possibility for a successful pregnancy.

Moretti, C., Lazzarin, N., De Felice, G., VAQUERO MARTIN, M.e., Manfellotto, D. (2012). Further evidence on the role of thyroid autoimmunity in women with recurrent miscarriage. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 1-4 [10.1155/2012/717185].

Further evidence on the role of thyroid autoimmunity in women with recurrent miscarriage

MORETTI, COSTANZO;VAQUERO MARTIN, MARIA ELENA;
2012-01-01

Abstract

It has been twenty years since the first paper reporting the association between thyroid antibodies (TAIs) and spontaneous miscarriage was published. Following this observation, several studies have clearly demonstrated an increased prevalence of TAI in patients with recurrent miscarriage (RM). However, the exact mechanism underlying this association remains a matter of debate. The aim of the present study was to evaluate the thyroid function, throughout a specific test, in patient with RM and TAI focusing on the hypothesis that TAI should be an indirect sign of a mild thyroid dysfunction. 46 patients with RMand TAI were included in the study. All patients underwent short TRH stimulation test showing an abnormal response in the vast majority of cases (65%). Normal FT4 and FT3 mean values were found whereas TSH values were in the upper normal range (2.64 ± 1.3mUI/L). Our data support the hypothesis that in patients with RM the presence of TAI is an indirect sign of a subtle thyroid dysfunction detectable by a specific test. This test give the possibility to identify women with RM in which specific therapeutic approaches could effectively improve the possibility for a successful pregnancy.
2012
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/13 - ENDOCRINOLOGIA
Settore MED/40 - GINECOLOGIA E OSTETRICIA
English
Con Impact Factor ISI
thyroid dysfunction; pregnancy
Moretti, C., Lazzarin, N., De Felice, G., VAQUERO MARTIN, M.e., Manfellotto, D. (2012). Further evidence on the role of thyroid autoimmunity in women with recurrent miscarriage. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 1-4 [10.1155/2012/717185].
Moretti, C; Lazzarin, N; De Felice, G; VAQUERO MARTIN, Me; Manfellotto, D
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/106695
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