Among the neuroactive steroids, 3alpha,5alpha-tetrahydrodeoxycorticosterone (3alpha,5alpha-THDOC) is at least in part produced in the adrenal gland and is therefore under the control of the hypothalamic-pituitary-adrenocortical (HPA) system. The antidepressant mirtazapine has been shown to attenuate HPA axis activity and to increase the concentrations of 3alpha-reduced metabolites of progesterone in depressed patients. In the present study, the impact of mirtazapine on 3alpha,5alpha-THDOC levels was investigated in relation to clinical response in depressed patients.
Schüle, C., Baghai, T., di Michele, F., Eser, D., Pasini, A., Romeo, E., et al. (2010). Mirtazapine does not influence tetrahydrodeoxycorticosterone levels in depressed patients. THE WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 11(2 Pt 2), 308-313 [10.3109/15622970701639429].
Mirtazapine does not influence tetrahydrodeoxycorticosterone levels in depressed patients
PASINI, AUGUSTO;ROMEO, ELENA;
2010-03-01
Abstract
Among the neuroactive steroids, 3alpha,5alpha-tetrahydrodeoxycorticosterone (3alpha,5alpha-THDOC) is at least in part produced in the adrenal gland and is therefore under the control of the hypothalamic-pituitary-adrenocortical (HPA) system. The antidepressant mirtazapine has been shown to attenuate HPA axis activity and to increase the concentrations of 3alpha-reduced metabolites of progesterone in depressed patients. In the present study, the impact of mirtazapine on 3alpha,5alpha-THDOC levels was investigated in relation to clinical response in depressed patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
