Introduction Treatment Resistant-Depression (TRD), known as the failure to respond to at least two different adequate trials of antidepressant treatments (ADT) in the current episode, is a relatively frequent clinical condition, associated to a high number of relapses, hospitalizations, and an elevated use of multiple pharmacological treatments. To date, however, the association between clinical variables and non-response in \{TRD\} remains unclear. Objectives To identify predictors of non-response in inpatients with Major Depressive Disorder (MDD) and TRD. Aims To investigate clinical variables as potential predictors of non-response in TRD. Methods Two hundred fifty-three inpatients with \{MDD\} and \{TRD\} were divided into two groups: responders and non-responders to drug therapies, according to a decrease of 50% or more of the severity of depression (measured with HAM-D 17 items) at the end of forth week of hospitalization. A general model of Cox regression (with backward stepwise method) was used to identify independent predictors of non-response to treatment. Results One hundred fifty-four \{TRD\} inpatients were responders and 99 non-responders. Cox regression identified three independent clinical predictors independently associated with the group of non-responders: (1) the presence of 5 or more depressive episodes in the medical history (OR = 2.27); (2) a current comorbid anxiety disorder (OR = 1.85); (3) a history of early life adversities (ELAs) (OR = 1.60). Conclusions The findings of this study suggest that the phenomenon of non-pharmacological response in the \{TRD\} is associated with different clinical variables, which might act through separate mechanisms in determining the persistence of depressive symptomatology.

DI LORENZO, G., Barone, Y., Daverio, A., Bianciardi, E., Ribolsi, M., Niolu, C., et al. (2014). Clinical predictors of non-response in 253 patients with treatment resistant-depression. EUROPEAN PSYCHIATRY, 29(S1), 1-1 [http://dx.doi.org/10.1016/S0924-9338(14)78705-X].

Clinical predictors of non-response in 253 patients with treatment resistant-depression

DI LORENZO, GIORGIO;BIANCIARDI, EMANUELA;RIBOLSI, MICHELE;NIOLU, CINZIA;SIRACUSANO, ALBERTO
2014-01-01

Abstract

Introduction Treatment Resistant-Depression (TRD), known as the failure to respond to at least two different adequate trials of antidepressant treatments (ADT) in the current episode, is a relatively frequent clinical condition, associated to a high number of relapses, hospitalizations, and an elevated use of multiple pharmacological treatments. To date, however, the association between clinical variables and non-response in \{TRD\} remains unclear. Objectives To identify predictors of non-response in inpatients with Major Depressive Disorder (MDD) and TRD. Aims To investigate clinical variables as potential predictors of non-response in TRD. Methods Two hundred fifty-three inpatients with \{MDD\} and \{TRD\} were divided into two groups: responders and non-responders to drug therapies, according to a decrease of 50% or more of the severity of depression (measured with HAM-D 17 items) at the end of forth week of hospitalization. A general model of Cox regression (with backward stepwise method) was used to identify independent predictors of non-response to treatment. Results One hundred fifty-four \{TRD\} inpatients were responders and 99 non-responders. Cox regression identified three independent clinical predictors independently associated with the group of non-responders: (1) the presence of 5 or more depressive episodes in the medical history (OR = 2.27); (2) a current comorbid anxiety disorder (OR = 1.85); (3) a history of early life adversities (ELAs) (OR = 1.60). Conclusions The findings of this study suggest that the phenomenon of non-pharmacological response in the \{TRD\} is associated with different clinical variables, which might act through separate mechanisms in determining the persistence of depressive symptomatology.
2014
Pubblicato
Rilevanza internazionale
Abstract
Esperti anonimi
Settore MED/25 - PSICHIATRIA
English
Con Impact Factor ISI
DI LORENZO, G., Barone, Y., Daverio, A., Bianciardi, E., Ribolsi, M., Niolu, C., et al. (2014). Clinical predictors of non-response in 253 patients with treatment resistant-depression. EUROPEAN PSYCHIATRY, 29(S1), 1-1 [http://dx.doi.org/10.1016/S0924-9338(14)78705-X].
DI LORENZO, G; Barone, Y; Daverio, A; Bianciardi, E; Ribolsi, M; Niolu, C; Siracusano, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/105773
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