At present, treatment for HIV-1 infection employs highly active anti-retroviral therapy (HAART), which utilizes a combination of RT and protease inhibitors. Unfortunately, HIV can escape many therapies because of its high mutation rate and the complexity of its pathogenesis. HIV-1 integrates into the cellular genome, which facilitates persistence and acts as a reservoir for reactivation and replication. As an alternative or adjuvant to chemotherapy we have been developing an RNA-based gene therapy approach for the treatment of HIV-1 infection. This article summarizes the various RNA based technologies that we have developed for potential application in a gene therapy setting.

Michienzi, A., Castanotto, D., Lee, N., Li, S., Zaia, J., Rossi, J. (2003). RNA-mediated inhibition of HIV in a gene therapy setting. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1002, 63-71.

RNA-mediated inhibition of HIV in a gene therapy setting

MICHIENZI, ALESSANDRO;
2003-12-01

Abstract

At present, treatment for HIV-1 infection employs highly active anti-retroviral therapy (HAART), which utilizes a combination of RT and protease inhibitors. Unfortunately, HIV can escape many therapies because of its high mutation rate and the complexity of its pathogenesis. HIV-1 integrates into the cellular genome, which facilitates persistence and acts as a reservoir for reactivation and replication. As an alternative or adjuvant to chemotherapy we have been developing an RNA-based gene therapy approach for the treatment of HIV-1 infection. This article summarizes the various RNA based technologies that we have developed for potential application in a gene therapy setting.
dic-2003
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/13 - BIOLOGIA APPLICATA
English
Con Impact Factor ISI
hematopoietic stem cells; hiv infections; gene therapy; rna interference; rna, catalytic; cell nucleolus; anti-hiv agents; hiv; rna, small interfering; humans
Michienzi, A., Castanotto, D., Lee, N., Li, S., Zaia, J., Rossi, J. (2003). RNA-mediated inhibition of HIV in a gene therapy setting. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1002, 63-71.
Michienzi, A; Castanotto, D; Lee, N; Li, S; Zaia, J; Rossi, J
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/10525
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