In eukaryotic cells the nuclear envelope isolates and protects DNA from molecules that could damage its structure or interfere with its processing. Moreover, selected protection enzymes and vitamins act as efficient guardians against toxic compounds both in the nucleoplasm and in the cytosol. The observation that a cytosolic detoxifying and antioxidant enzyme i.e. glutathione transferase is accumulated in the perinuclear region of the rat hepatocytes suggests that other unrecognized modalities of nuclear protection may exist. Here we show evidence for the existence of a safeguard enzyme machinery formed by an hyper-crowding of cationic enzymes and proteins encompassing the nuclear membrane and promoted by electrostatic interactions.

Fabrini, R., Bocedi, A., Pallottini, V., Canuti, L., De Canio, M., Urbani, A., et al. (2010). Nuclear shield: a multi-enzyme task-force for nucleus protection. PLOS ONE, 5(12), e14125 [10.1371/journal.pone.0014125].

Nuclear shield: a multi-enzyme task-force for nucleus protection

Bocedi, A;URBANI, ANDREA;STELLA, LORENZO;CANINI, ANTONELLA;FEDERICI, GIORGIO;RICCI, GIORGIO
2010-01-01

Abstract

In eukaryotic cells the nuclear envelope isolates and protects DNA from molecules that could damage its structure or interfere with its processing. Moreover, selected protection enzymes and vitamins act as efficient guardians against toxic compounds both in the nucleoplasm and in the cytosol. The observation that a cytosolic detoxifying and antioxidant enzyme i.e. glutathione transferase is accumulated in the perinuclear region of the rat hepatocytes suggests that other unrecognized modalities of nuclear protection may exist. Here we show evidence for the existence of a safeguard enzyme machinery formed by an hyper-crowding of cationic enzymes and proteins encompassing the nuclear membrane and promoted by electrostatic interactions.
2010
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/10 - BIOCHIMICA
English
Con Impact Factor ISI
Fabrini, R., Bocedi, A., Pallottini, V., Canuti, L., De Canio, M., Urbani, A., et al. (2010). Nuclear shield: a multi-enzyme task-force for nucleus protection. PLOS ONE, 5(12), e14125 [10.1371/journal.pone.0014125].
Fabrini, R; Bocedi, A; Pallottini, V; Canuti, L; De Canio, M; Urbani, A; Marzano, V; Cornetta, T; Stano, P; Giovanetti, A; Stella, L; Canini, A; Feder...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/10362
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