MicroRNAs are highly conserved, noncoding RNAs involved in post-transcriptional gene silencing. They have been shown to participate in a wide range of biological processes, including myogenesis and muscle regeneration. The goal of this study is to test the hypothesis that myo-miRs (myo = muscle + miR = miRNA) expression is altered in muscle from patients affected by myotonic dystrophy type 1 (DM1), the most frequently inherited neuromuscular disease in adults. In order to gain better insights about the role of miRNAs in the DM1 pathogenesis, we have also analyzed the muscular expression of miR-103 and miR-107, which have been identified in silico as attractive candidates for binding to the DMPK mRNA.
Gambardella, S., Rinaldi, F., Lepore, S., Viola, A., Loro, E., Angelini, C., et al. (2010). Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients. JOURNAL OF TRANSLATIONAL MEDICINE, 8, 48 [10.1186/1479-5876-8-48].
Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients
GAMBARDELLA, SERGIO;NOVELLI, GIUSEPPE;BOTTA, ANNALISA
2010-01-01
Abstract
MicroRNAs are highly conserved, noncoding RNAs involved in post-transcriptional gene silencing. They have been shown to participate in a wide range of biological processes, including myogenesis and muscle regeneration. The goal of this study is to test the hypothesis that myo-miRs (myo = muscle + miR = miRNA) expression is altered in muscle from patients affected by myotonic dystrophy type 1 (DM1), the most frequently inherited neuromuscular disease in adults. In order to gain better insights about the role of miRNAs in the DM1 pathogenesis, we have also analyzed the muscular expression of miR-103 and miR-107, which have been identified in silico as attractive candidates for binding to the DMPK mRNA.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
