Acute pancreatitis (AP) is a serious medical condition usually associated with severe upper abdominal pain. The purpose of our study is to assess the therapeutic consequences of contrast-enhanced computed tomography (CE-CT) and the predictive value of CRP for severe pancreatitis. We included patients with a threefold increase of plasma lipase who had received a CE-CT or had a CRP of =150 mg/dl. A total of 74 out of 283 patients got a contrast-enhanced CT scan; in 11 cases the CT was followed by endoscopic or surgical interventions as therapeutic consequences compared with 19 out of 50 control cases. 69 out of 283 patients (24,3%) had CRP >150 mg/dl within 48 hours after admission. 32 of them had SAP. The CRP cutoff of 150 mg/L had a sensitivity of 80% and a specificity of 65%. The positive predictive value for SAP in patients beyond the cutoff is 46.4%. The negative predictive value for SAP in patients below the cutoff was 89.5%. Our results support the opinion that an early CE-CT is usually not indicated. CRP helps to assess the course of AP; levels below 150 mg/dl between the first 48 h indicate a mild course in most of the cases.

Nistal, M., Zoltani, M., Lohse, A., DI DANIELE, N., Tesauro, M., Pace, A. (2014). Analysis of the power of common diagnostic tools in the management of acute pancreatitis. GASTROENTEROLOGY RESEARCH AND PRACTICE, 2014, 438697-438697 [10.1155/2014/438697].

Analysis of the power of common diagnostic tools in the management of acute pancreatitis

DI DANIELE, NICOLA;TESAURO, MANFREDI;
2014-01-01

Abstract

Acute pancreatitis (AP) is a serious medical condition usually associated with severe upper abdominal pain. The purpose of our study is to assess the therapeutic consequences of contrast-enhanced computed tomography (CE-CT) and the predictive value of CRP for severe pancreatitis. We included patients with a threefold increase of plasma lipase who had received a CE-CT or had a CRP of =150 mg/dl. A total of 74 out of 283 patients got a contrast-enhanced CT scan; in 11 cases the CT was followed by endoscopic or surgical interventions as therapeutic consequences compared with 19 out of 50 control cases. 69 out of 283 patients (24,3%) had CRP >150 mg/dl within 48 hours after admission. 32 of them had SAP. The CRP cutoff of 150 mg/L had a sensitivity of 80% and a specificity of 65%. The positive predictive value for SAP in patients beyond the cutoff is 46.4%. The negative predictive value for SAP in patients below the cutoff was 89.5%. Our results support the opinion that an early CE-CT is usually not indicated. CRP helps to assess the course of AP; levels below 150 mg/dl between the first 48 h indicate a mild course in most of the cases.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/09 - Medicina Interna
English
Nistal, M., Zoltani, M., Lohse, A., DI DANIELE, N., Tesauro, M., Pace, A. (2014). Analysis of the power of common diagnostic tools in the management of acute pancreatitis. GASTROENTEROLOGY RESEARCH AND PRACTICE, 2014, 438697-438697 [10.1155/2014/438697].
Nistal, M; Zoltani, M; Lohse, A; DI DANIELE, N; Tesauro, M; Pace, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/103315
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