Training Effects On Laboratory Parameters Are Independent By Genetic Polymorphisms Of Il-10 And Tnf-Alpha

Background: It is well known that exercise has beneficial effects on health. Although intense exercise is experienced by the body as a condition of stress,a well designed training has long term beneficial effects on the organism of an athlete. Less it is known about the effects that the genetic background might have on training adaptation and on the consequent modification of laboratory parameters. Methods: In our study we evaluated the blood chemistry parameters of a group of 41 athletes compared with a group of 45 amateur athletes, to assess whether the training has effects on their variation. In addition we typed our subjects for polymorphisms -308 A/G of the Tumor Necrosis Factor-α (TNFα) and -1082 A/G of Interleukin-10 (IL10), Results: After statistical analysis, performed with Mann-Whitney Test, we can observe a statistically significant (p value< 0,05) increase of basophils, eosinophils, monocytes, and total bilirubin and decreased levels of neutrophils, glucose, electrolytes and AST in professionals than amateurs. These parameters were not modified by the genetic background. Actually the training modification observed were independent by the presence of pro-inflammatory (carrier allele A of -1082 A/G of IL10) or anti-inflammatory alleles (subjects A negative for -308 A/G of TNF) Conclusion: The genetic polymorphisms analyzed do not influence changes in laboratory parameters values induced by professional training.