The pattern of associations between maternal phosphoglucomutase locus 1 (PGM1) and foetal macrosomia in diabetic pregnancy has been compared with that observed in normal pregnancy. In diabetic pregnancy a substantial increase of macrosomic infants, as compared to normal pregnancy, is observed only among women homozygous for PGM1(1) allele. Also neonatal hypoglycemia is much more frequent in newborns from PGM1(-1) mothers than in newborns from other mothers. Since enzymatic activity of PGM1(-1) phenotype is lower as compared to other PGM1 phenotypes, this may influence glycaemic level and/or its stability in diabetic pregnant women with unfavourable effects on the metabolic and developmental patterns of the foetus
Lucarini, N., Gerlini, G., Gloria Bottini, F., Gori, M., Borgiani, P., Caprella, M., et al. (1987). Foetal macrosomia in diabetic pregnancy. Further data on the association with maternal PGM1 genotype. DIABETES RESEARCH, 5(4), 169-174.
Foetal macrosomia in diabetic pregnancy. Further data on the association with maternal PGM1 genotype
BORGIANI, PAOLA;BOTTINI, EGIDIO
1987-01-01
Abstract
The pattern of associations between maternal phosphoglucomutase locus 1 (PGM1) and foetal macrosomia in diabetic pregnancy has been compared with that observed in normal pregnancy. In diabetic pregnancy a substantial increase of macrosomic infants, as compared to normal pregnancy, is observed only among women homozygous for PGM1(1) allele. Also neonatal hypoglycemia is much more frequent in newborns from PGM1(-1) mothers than in newborns from other mothers. Since enzymatic activity of PGM1(-1) phenotype is lower as compared to other PGM1 phenotypes, this may influence glycaemic level and/or its stability in diabetic pregnant women with unfavourable effects on the metabolic and developmental patterns of the foetusI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
