Nanodiamonds are a novel class of nanomaterials which have raised much attention for application in biomedical field, as they combine the possibility of being produced on large scale using relatively inexpensive synthetic processes, of being fluorescent as a consequence of the presence of nitrogen vacancies, of having their surfaces functionalized, and of having good biocompatibility. Among other applications, we mainly focus on drug delivery, including cell interaction, targeting, cancer therapy, gene and protein delivery. In addition, nanodiamonds for bone and dental implants and for antibacterial use is discussed. Techniques for detection and imaging of nanodiamonds in biological tissues are also reviewed, including electron microscopy, fluorescence microscopy, Raman mapping, atomic force microscopy, thermal imaging, magnetic resonance imaging, and positron emission tomography, either in vitro, in vivo, or ex vivo. Toxicological aspects related to the use of nanodiamonds are also discussed. Finally, patents, preclinical and clinical trials based on the use of nanodiamonds for biomedical applications are reviewed.

Passeri, D., Rinaldi, F., Ingallina, C., Carafa, M., Rossi, M., TERRANOVA PERSICHELLI, M.l., et al. (2015). Biomedical applications of nanodiamonds: An overview. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 15(2), 972-988 [10.1166/jnn.2015.9734].

Biomedical applications of nanodiamonds: An overview

TERRANOVA PERSICHELLI, MARIA LETIZIA;
2015-01-01

Abstract

Nanodiamonds are a novel class of nanomaterials which have raised much attention for application in biomedical field, as they combine the possibility of being produced on large scale using relatively inexpensive synthetic processes, of being fluorescent as a consequence of the presence of nitrogen vacancies, of having their surfaces functionalized, and of having good biocompatibility. Among other applications, we mainly focus on drug delivery, including cell interaction, targeting, cancer therapy, gene and protein delivery. In addition, nanodiamonds for bone and dental implants and for antibacterial use is discussed. Techniques for detection and imaging of nanodiamonds in biological tissues are also reviewed, including electron microscopy, fluorescence microscopy, Raman mapping, atomic force microscopy, thermal imaging, magnetic resonance imaging, and positron emission tomography, either in vitro, in vivo, or ex vivo. Toxicological aspects related to the use of nanodiamonds are also discussed. Finally, patents, preclinical and clinical trials based on the use of nanodiamonds for biomedical applications are reviewed.
2015
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore CHIM/03 - CHIMICA GENERALE E INORGANICA
English
Con Impact Factor ISI
Biomedicine; Diagnostic; Drug delivery; Imaging; Nanodiamond; Theranostic; Therapy;
Nanodiamond ; Biomedicine ; Drug Delivery; Diagnostic; Imaging ; Therapy; Theranostic
Passeri, D., Rinaldi, F., Ingallina, C., Carafa, M., Rossi, M., TERRANOVA PERSICHELLI, M.l., et al. (2015). Biomedical applications of nanodiamonds: An overview. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 15(2), 972-988 [10.1166/jnn.2015.9734].
Passeri, D; Rinaldi, F; Ingallina, C; Carafa, M; Rossi, M; TERRANOVA PERSICHELLI, Ml; Marianecci, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/100820
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