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EnglishAbstract OBJECTIVES: To evaluate the role of 18-fluoro-2-deoxyglucose positron emission tomography-computed tomography ((18)F-FDG-PET-CT) in the diagnosis of infectious endocarditis (IE). METHODS: We retrospectively examined 27 consecutive patients who were admitted to the Infectious Diseases Department of Tor Vergata University Hospital between 2009 and 2013 with a suspicion of IE. The final IE diagnosis was defined according to the modified Duke criteria, and the microbiological and diagnostic results were collected for each patient. RESULTS: Twenty out of 27 patients had a suspected prosthetic valve endocarditis (PVE) and seven had a suspected native valve endocarditis (NVE). Twenty-five out of 27 patients (92%) had a confirmed diagnosis of IE (18/25 PVE and 7/25 NVE); 16 had a positive echocardiography evaluation and 16 had positive (18)F-FDG-PET-CT findings. Echocardiography showed a higher sensitivity as a diagnostic tool for the detection of IE compared to (18)F-FDG-PET-CT (80% vs. 55%). However, a greater number of PVE had positive (18)F-FDG-PET-CT results compared to those with positive echocardiography findings (11/13 vs. 9/13), and overall 89% (16/18) of confirmed PVE resulted (18)F-FDG-PET-CT positive. Analyzing only the cases who underwent transoesophageal echocardiography, (18)F-FDG-PET-CT showed a sensitivity of 85% in PVE (vs. 69% for echocardiography and 77% for the Duke criteria). All seven patients with NVE had a positive echocardiography and negative (18)F-FDG-PET-CT findings (p<0.001). CONCLUSIONS: The results of this study further highlight the limitations of echocardiography in the diagnosis of PVE and the potential advantages of (18)F-FDG-PET-CT in these cases.
Ricciardi, A., Sordillo, P., Ceccarelli, L., Maffongelli, G., Calisti, G., Di Pietro, B., et al. (2014). 18-Fluoro-2-deoxyglucose positron emission tomography-computed tomography: an additional tool in the diagnosis of prosthetic valve endocarditis. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 28, 219-224.
| Tipologia: | Articolo su rivista |
| Citazione: | Ricciardi, A., Sordillo, P., Ceccarelli, L., Maffongelli, G., Calisti, G., Di Pietro, B., et al. (2014). 18-Fluoro-2-deoxyglucose positron emission tomography-computed tomography: an additional tool in the diagnosis of prosthetic valve endocarditis. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 28, 219-224. |
| URL: | http://www.sciencedirect.com/science/article/pii/S1201971214015252 |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore MED/17 - Malattie Infettive Settore MED/36 - Diagnostica per Immagini e Radioterapia |
| Revisione (peer review): | Esperti anonimi |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.ijid.2014.04.028 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | nov-2014 |
| Titolo: | 18-Fluoro-2-deoxyglucose positron emission tomography-computed tomography: an additional tool in the diagnosis of prosthetic valve endocarditis. |
| Autori: | |
| Autori: | Ricciardi, A; Sordillo, P; Ceccarelli, L; Maffongelli, G; Calisti, G; Di Pietro, B; Caracciolo, CR; Schillaci, O; Pellegrino, A; Chiariello, L; Andreoni, M; Sarmati, L |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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