Abstract OBJECTIVES: To evaluate the role of 18-fluoro-2-deoxyglucose positron emission tomography-computed tomography ((18)F-FDG-PET-CT) in the diagnosis of infectious endocarditis (IE). METHODS: We retrospectively examined 27 consecutive patients who were admitted to the Infectious Diseases Department of Tor Vergata University Hospital between 2009 and 2013 with a suspicion of IE. The final IE diagnosis was defined according to the modified Duke criteria, and the microbiological and diagnostic results were collected for each patient. RESULTS: Twenty out of 27 patients had a suspected prosthetic valve endocarditis (PVE) and seven had a suspected native valve endocarditis (NVE). Twenty-five out of 27 patients (92%) had a confirmed diagnosis of IE (18/25 PVE and 7/25 NVE); 16 had a positive echocardiography evaluation and 16 had positive (18)F-FDG-PET-CT findings. Echocardiography showed a higher sensitivity as a diagnostic tool for the detection of IE compared to (18)F-FDG-PET-CT (80% vs. 55%). However, a greater number of PVE had positive (18)F-FDG-PET-CT results compared to those with positive echocardiography findings (11/13 vs. 9/13), and overall 89% (16/18) of confirmed PVE resulted (18)F-FDG-PET-CT positive. Analyzing only the cases who underwent transoesophageal echocardiography, (18)F-FDG-PET-CT showed a sensitivity of 85% in PVE (vs. 69% for echocardiography and 77% for the Duke criteria). All seven patients with NVE had a positive echocardiography and negative (18)F-FDG-PET-CT findings (p<0.001). CONCLUSIONS: The results of this study further highlight the limitations of echocardiography in the diagnosis of PVE and the potential advantages of (18)F-FDG-PET-CT in these cases.
Ricciardi, A., Sordillo, P., Ceccarelli, L., Maffongelli, G., Calisti, G., Di Pietro, B., et al. (2014). 18-Fluoro-2-deoxyglucose positron emission tomography-computed tomography: an additional tool in the diagnosis of prosthetic valve endocarditis. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 28, 219-224.
|Tipologia:||Articolo su rivista|
|Citazione:||Ricciardi, A., Sordillo, P., Ceccarelli, L., Maffongelli, G., Calisti, G., Di Pietro, B., et al. (2014). 18-Fluoro-2-deoxyglucose positron emission tomography-computed tomography: an additional tool in the diagnosis of prosthetic valve endocarditis. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 28, 219-224.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
Settore MED/36 - Diagnostica per Immagini e Radioterapia
|Revisione (peer review):||Esperti anonimi|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ijid.2014.04.028|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||nov-2014|
|Titolo:||18-Fluoro-2-deoxyglucose positron emission tomography-computed tomography: an additional tool in the diagnosis of prosthetic valve endocarditis.|
|Autori:||Ricciardi, A; Sordillo, P; Ceccarelli, L; Maffongelli, G; Calisti, G; Di Pietro, B; Caracciolo, CR; Schillaci, O; Pellegrino, A; Chiariello, L; Andreoni, M; Sarmati, L|
|Appare nelle tipologie:||01 - Articolo su rivista|