Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the digestive tract characterized, in the majority of cases, by activating mutations in the KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) or PDGFRA (platelet-derived growth factor receptor, alpha polypeptide) genes. Mutations affecting these tyrosine kinase receptors are also responsible for the mechanisms of primary and secondary drug resistance during the treatment with tyrosine kinase inhibitors. We performed mutational analysis to evaluate the pharmacotherapy susceptibility of GISTs, adopting a comprehensive procedural approach, in order to optimize the identification of mutations that may result in cellular resistance to conventional therapy.

Palmirotta, R., De Marchis, M., Ludovici, G., Leone, B., Covello, R., Conti, S., et al. (2013). Mutational analysis of gastrointestinal stromal tumors (GISTs): procedural approach for diagnostic purposes. CANCER GENOMICS & PROTEOMICS., 10(3), 115-123.

Mutational analysis of gastrointestinal stromal tumors (GISTs): procedural approach for diagnostic purposes

DELLA MORTE, DAVID;ROSELLI, MARIO;
2013-05-01

Abstract

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the digestive tract characterized, in the majority of cases, by activating mutations in the KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) or PDGFRA (platelet-derived growth factor receptor, alpha polypeptide) genes. Mutations affecting these tyrosine kinase receptors are also responsible for the mechanisms of primary and secondary drug resistance during the treatment with tyrosine kinase inhibitors. We performed mutational analysis to evaluate the pharmacotherapy susceptibility of GISTs, adopting a comprehensive procedural approach, in order to optimize the identification of mutations that may result in cellular resistance to conventional therapy.
mag-2013
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/06 - ONCOLOGIA MEDICA
English
Con Impact Factor ISI
Proto-Oncogene Proteins c-kit; pharmacogenomics; Exons; DNA Mutational Analysis; Humans; Aged; Gastrointestinal stromal tumors; KIT; Aged, 80 and over; Receptor, Platelet-Derived Growth Factor alpha; Adult; PDGFRA; Middle Aged; mutational analysis; Gastrointestinal Stromal Tumors; Mutation; Male; Female
Palmirotta, R., De Marchis, M., Ludovici, G., Leone, B., Covello, R., Conti, S., et al. (2013). Mutational analysis of gastrointestinal stromal tumors (GISTs): procedural approach for diagnostic purposes. CANCER GENOMICS & PROTEOMICS., 10(3), 115-123.
Palmirotta, R; De Marchis, M; Ludovici, G; Leone, B; Covello, R; Conti, S; Costarelli, L; DELLA MORTE, D; Ferroni, P; Roselli, M; Guadagni, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/100167
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