TNF-α has been proposed as a predictive factor for venous thromboembolism (VTE). Genetic polymorphisms could regulate TNF-α production. However, the relationship between TNFA gene variants and VTE is not clarified. This study aims to investigate the predictive role of five different TNFA gene promoter SNPs, or their haplotype combination(s), for a first VTE episode in gastrointestinal cancer out-patients treated with chemotherapy.

Roselli, M., Ferroni, P., Rolfo, C., Peeters, M., Palmirotta, R., Formica, V., et al. (2013). TNF-α gene promoter polymorphisms and risk of venous thromboembolism in gastrointestinal cancer patients undergoing chemotherapy. ANNALS OF ONCOLOGY, 24(10), 2571-2575 [10.1093/annonc/mdt251].

TNF-α gene promoter polymorphisms and risk of venous thromboembolism in gastrointestinal cancer patients undergoing chemotherapy

ROSELLI, MARIO;Formica, V;RUSSO, MARIO ANTONIO;
2013-10-01

Abstract

TNF-α has been proposed as a predictive factor for venous thromboembolism (VTE). Genetic polymorphisms could regulate TNF-α production. However, the relationship between TNFA gene variants and VTE is not clarified. This study aims to investigate the predictive role of five different TNFA gene promoter SNPs, or their haplotype combination(s), for a first VTE episode in gastrointestinal cancer out-patients treated with chemotherapy.
ott-2013
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/06 - ONCOLOGIA MEDICA
English
Polymorphism, Single Nucleotide; Antimetabolites, Antineoplastic; single nucleotide polymorphisms; Humans; Retrospective Studies; Aged; Promoter Regions, Genetic; Haplotypes; Aged, 80 and over; Adult; gastrointestinal cancer; Genetic Predisposition to Disease; Male; tumour necrosis factor-α; Tumor Necrosis Factor-alpha; Venous Thromboembolism; Camptothecin; chemotherapy; Risk; Fluorouracil; Case-Control Studies; Gastrointestinal Neoplasms; Middle Aged; venous thromboembolism; Antineoplastic Agents, Phytogenic; Female
Roselli, M., Ferroni, P., Rolfo, C., Peeters, M., Palmirotta, R., Formica, V., et al. (2013). TNF-α gene promoter polymorphisms and risk of venous thromboembolism in gastrointestinal cancer patients undergoing chemotherapy. ANNALS OF ONCOLOGY, 24(10), 2571-2575 [10.1093/annonc/mdt251].
Roselli, M; Ferroni, P; Rolfo, C; Peeters, M; Palmirotta, R; Formica, V; Ludovici, G; Laudisi, A; De Marchis, M; La Farina, F; Russo, Ma; Guadagni, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/100159
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