Dual/mixed-tropic HIV-1 strains are predominant in a significant proportion of patients, though little information is available regarding their replication-capacity and susceptibility against CCR5-antagonists in-vitro. The aim of the study was to analyze the replication-capacity and susceptibility to maraviroc of HIV-1 clinical isolates with different tropism characteristics in primary monocyte-derived-macrophages (MDM), peripheral-blood-mononuclear-cells (PBMC), and CD4(+) T-lymphocytes.

Surdo, M., Balestra, E., Saccomandi, P., DI SANTO, F., Montano, M., Di Carlo, D., et al. (2013). Inhibition of dual/mixed tropic HIV-1 isolates by CCR5-inhibitors in primary lymphocytes and macrophages. PLOS ONE, 8(7), e68076-e68076 [10.1371/journal.pone.0068076].

Inhibition of dual/mixed tropic HIV-1 isolates by CCR5-inhibitors in primary lymphocytes and macrophages

BALESTRA, EMANUELA;SACCOMANDI, PATRIZIA;DI SANTO, FABIOLA;MONTANO, MARCO;SARMATI, LOREDANA;AQUARO, STEFANO;ANDREONI, MASSIMO;SVICHER, VALENTINA;PERNO, CARLO FEDERICO;CECCHERINI SILBERSTEIN, FRANCESCA
2013-07-09

Abstract

Dual/mixed-tropic HIV-1 strains are predominant in a significant proportion of patients, though little information is available regarding their replication-capacity and susceptibility against CCR5-antagonists in-vitro. The aim of the study was to analyze the replication-capacity and susceptibility to maraviroc of HIV-1 clinical isolates with different tropism characteristics in primary monocyte-derived-macrophages (MDM), peripheral-blood-mononuclear-cells (PBMC), and CD4(+) T-lymphocytes.
9-lug-2013
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
Virus Replication; Macrophages; Anti-HIV Agents; Leukocytes, Mononuclear; Gene Expression Regulation, Viral; Humans; Viral Tropism; Receptors, CCR5; Lymphocytes; HIV-1; Genotype; Phenotype; Receptors, CXCR4; Cell Line
Surdo, M., Balestra, E., Saccomandi, P., DI SANTO, F., Montano, M., Di Carlo, D., et al. (2013). Inhibition of dual/mixed tropic HIV-1 isolates by CCR5-inhibitors in primary lymphocytes and macrophages. PLOS ONE, 8(7), e68076-e68076 [10.1371/journal.pone.0068076].
Surdo, M; Balestra, E; Saccomandi, P; DI SANTO, F; Montano, M; Di Carlo, D; Sarmati, L; Aquaro, S; Andreoni, M; Svicher, V; Perno, Cf; CECCHERINI SILBERSTEIN, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/89908
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