In order to attain a finer reconstruction of the peopling of southern and central-eastem Europe from the Levant, we determined the frequencies of eight lineages internal to the Y chromosomal haplogroup J, defined by biallelic markers, in 22 population samples obtained with a fine-grained sampling scheme. Our results partially resolve a major multifurcation of lineages within the haplogroup. Analyses of molecular variance show that the area covered by haplogroup J dispersal is characterized by a significant degree of molecular radiation for unique event polymorphisms within the haplogroup, with a higher incidence of the most derived sub-haplogroups on the northern Mediterranean coast, from Turkey westward; here, J diversity is not simply a subset of that present in the area in which this haplogroup, first originated. Dating estimates, based on simple tandem repeat loci (STR) diversity within each lineage, confirmed the presence of a major population structuring at the time of spread of haplogroup J in Europe and a punctuation in the peopling of this continent in the post-Neolithic, compatible with the expansion of the Greek world. We also present here, for the first time, a novel method for comparative dating of lineages, free of assumptions of STR mutation rates.

Di Giacomo, F., Luca, F., Popa, L., Akar, N., Anagnou, N., Banyko, J., et al. (2004). Y chromosomal haplogroup J as a signature of the post-neolithic colonization of Europe. HUMAN GENETICS, 115(5), 357-371 [10.1007/s00439-004-1168-9].

Y chromosomal haplogroup J as a signature of the post-neolithic colonization of Europe

TERRENATO, LUCIANO;MALASPINA, PATRIZIA;NOVELLETTO, ANDREA
2004-01-01

Abstract

In order to attain a finer reconstruction of the peopling of southern and central-eastem Europe from the Levant, we determined the frequencies of eight lineages internal to the Y chromosomal haplogroup J, defined by biallelic markers, in 22 population samples obtained with a fine-grained sampling scheme. Our results partially resolve a major multifurcation of lineages within the haplogroup. Analyses of molecular variance show that the area covered by haplogroup J dispersal is characterized by a significant degree of molecular radiation for unique event polymorphisms within the haplogroup, with a higher incidence of the most derived sub-haplogroups on the northern Mediterranean coast, from Turkey westward; here, J diversity is not simply a subset of that present in the area in which this haplogroup, first originated. Dating estimates, based on simple tandem repeat loci (STR) diversity within each lineage, confirmed the presence of a major population structuring at the time of spread of haplogroup J in Europe and a punctuation in the peopling of this continent in the post-Neolithic, compatible with the expansion of the Greek world. We also present here, for the first time, a novel method for comparative dating of lineages, free of assumptions of STR mutation rates.
2004
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/18 - GENETICA
English
Con Impact Factor ISI
DNA; allele; article; controlled study; DNA determination; Eastern Europe; gene locus; genetic polymorphism; genetic variability; Greece; haplotype; human; human cell; human experiment; incidence; male; marker gene; mutation rate; phylogeny; population dispersal; population genetics; population structure; priority journal; sampling; single nucleotide polymorphism; Southern Europe; tandem repeat; Turkey (republic); Y chromosome; Africa, Northern; chromosomes, human, Y; emigration and immigration; Europe; haplotypes; humans; male; phylogeny; polymorphism, genetic; tandem repeat sequences; variation (Genetics)
Di Giacomo, F., Luca, F., Popa, L., Akar, N., Anagnou, N., Banyko, J., et al. (2004). Y chromosomal haplogroup J as a signature of the post-neolithic colonization of Europe. HUMAN GENETICS, 115(5), 357-371 [10.1007/s00439-004-1168-9].
Di Giacomo, F; Luca, F; Popa, L; Akar, N; Anagnou, N; Banyko, J; Brdicka, R; Barbujani, G; Papola, F; Ciavarella, G; Cucci, F; Di Stasi, L; Gavrila, L; Kerimova, M; Kovatchev, D; Kozlov, A; Loutradis, A; Mandarino, V; Mammì, C; Michalodimitrakis, E; Paoli, G; Pappa, K; Pedicini, G; Terrenato, L; Tofanelli, S; Malaspina, P; Novelletto, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/8738
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