Glutaredoxin 1 (Grx1), a small protein belonging to the thioredoxin family, is involved in redox-regulation since it catalyzes the reduction of protein disulfides and that of mixed disulfides. It was reported to modulate active copper extrusion from cells, by affecting the function of the pumps ATP7A and B. These are components of the network of protein chaperones involved in the control of the homeostasis of copper, an essential, though harmful, metal. However, the effect of Grx1 on copper levels, copper chaperones and copper-elicited cell toxicity was never investigated.
De Benedetto, M., Capo, C.r., Ferri, A., Valle, C., Polimanti, R., Carri', M.t., et al. (2014). Glutaredoxin 1 is a major player in copper metabolism in neuroblastoma cells. BIOCHIMICA ET BIOPHYSICA ACTA, 1840(1), 255-261 [10.1016/j.bbagen.2013.09.008].
Glutaredoxin 1 is a major player in copper metabolism in neuroblastoma cells
CAPO, CONCETTA ROSA;CARRI', MARIA TERESA;ROSSI, LUISA
2014-01-01
Abstract
Glutaredoxin 1 (Grx1), a small protein belonging to the thioredoxin family, is involved in redox-regulation since it catalyzes the reduction of protein disulfides and that of mixed disulfides. It was reported to modulate active copper extrusion from cells, by affecting the function of the pumps ATP7A and B. These are components of the network of protein chaperones involved in the control of the homeostasis of copper, an essential, though harmful, metal. However, the effect of Grx1 on copper levels, copper chaperones and copper-elicited cell toxicity was never investigated.| File | Dimensione | Formato | |
|---|---|---|---|
|
BBAGEN_2013.pdf
solo utenti autorizzati
Licenza:
Non specificato
Dimensione
716.14 kB
Formato
Adobe PDF
|
716.14 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
