Microbubbles are often used as ultrasound contrast agents for sonography. However, polymer-shelled microbubbles have the potential to support also additional functionalities such as, for example, targeted drug delivery. Using digital holographic microscopy we demonstrate that structural information on individual bubbles can be retrieved with high precision combined with low costs and short acquisition time. We have characterized the distributions of size, shell thickness and refractive index for hundreds of polymeric microbubbles showing that shell thickness displays a large variation that is strongly correlated with its refractive index. A large thickness corresponds to a smaller refractive index indicating a possible mechanism of progressive shell swelling with water.

Saglimbeni, F., Bianchi, S., Bolognesi, G., Paradossi, G., Di Leonardo, R. (2012). Optical characterization of an individual polymer-shelled microbubble structure via digital holography. SOFT MATTER, 8, 8822-8825 [10.1039/C2SM26099A].

Optical characterization of an individual polymer-shelled microbubble structure via digital holography

PARADOSSI, GAIO;
2012-01-01

Abstract

Microbubbles are often used as ultrasound contrast agents for sonography. However, polymer-shelled microbubbles have the potential to support also additional functionalities such as, for example, targeted drug delivery. Using digital holographic microscopy we demonstrate that structural information on individual bubbles can be retrieved with high precision combined with low costs and short acquisition time. We have characterized the distributions of size, shell thickness and refractive index for hundreds of polymeric microbubbles showing that shell thickness displays a large variation that is strongly correlated with its refractive index. A large thickness corresponds to a smaller refractive index indicating a possible mechanism of progressive shell swelling with water.
2012
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore CHIM/02 - CHIMICA FISICA
English
Saglimbeni, F., Bianchi, S., Bolognesi, G., Paradossi, G., Di Leonardo, R. (2012). Optical characterization of an individual polymer-shelled microbubble structure via digital holography. SOFT MATTER, 8, 8822-8825 [10.1039/C2SM26099A].
Saglimbeni, F; Bianchi, S; Bolognesi, G; Paradossi, G; Di Leonardo, R
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/84767
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 19
social impact