Angioimmunoblastic T-cell lymphoma shows a high release of cytokines. Different blood purification techniques are employed to control hypercytokinemia. Here we investigated the effects of intermittent supra-hemodiafiltration with endogenous reinfusion on cytokine removal in a patient presenting with acute kidney injury. After the first day of chemotherapy for angioimmunoblastic T-cell lymphoma, a 78-year-old male patient developed acute kidney injury and systemic inflammatory response syndrome due to massive release of inflammatory cytokines. Three sessions of supra-hemodiafiltration were performed. Blood samples for evaluation of renal function and inflammatory mediators were collected at the beginning and the end of each dialytic session. A marked improvement of clinical state and renal function was associated to a significant reduction of inflammatory markers. Our results suggest that renal replacement therapy with supra-hemodiafiltration may remove a wide spectrum of inflammatory mediators and uremic toxins involved in acute kidney injury and systemic inflammatory response syndrome.

Staffolani, E., Nicolais, R., MANCA DI VILLAHERMOSA, S., Galli, D., Postorino, M., DI DANIELE, N. (2012). Cytokine removal under hemodiafiltration with endogenous reinfusion in acute kidney injury secondary to angioimmunoblastic T-cell lymphoma: a case report. BLOOD PURIFICATION, 34(3-4), 349-353 [10.1159/000346288].

Cytokine removal under hemodiafiltration with endogenous reinfusion in acute kidney injury secondary to angioimmunoblastic T-cell lymphoma: a case report

MANCA DI VILLAHERMOSA, SIMONE;POSTORINO, MASSIMILIANO;DI DANIELE, NICOLA
2012-01-01

Abstract

Angioimmunoblastic T-cell lymphoma shows a high release of cytokines. Different blood purification techniques are employed to control hypercytokinemia. Here we investigated the effects of intermittent supra-hemodiafiltration with endogenous reinfusion on cytokine removal in a patient presenting with acute kidney injury. After the first day of chemotherapy for angioimmunoblastic T-cell lymphoma, a 78-year-old male patient developed acute kidney injury and systemic inflammatory response syndrome due to massive release of inflammatory cytokines. Three sessions of supra-hemodiafiltration were performed. Blood samples for evaluation of renal function and inflammatory mediators were collected at the beginning and the end of each dialytic session. A marked improvement of clinical state and renal function was associated to a significant reduction of inflammatory markers. Our results suggest that renal replacement therapy with supra-hemodiafiltration may remove a wide spectrum of inflammatory mediators and uremic toxins involved in acute kidney injury and systemic inflammatory response syndrome.
2012
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/14 - NEFROLOGIA
English
Blood Chemical Analysis; Hemodiafiltration; Humans; Immunoblastic Lymphadenopathy; Acute Kidney Injury; Cytokines; Aged; Male
Staffolani, E., Nicolais, R., MANCA DI VILLAHERMOSA, S., Galli, D., Postorino, M., DI DANIELE, N. (2012). Cytokine removal under hemodiafiltration with endogenous reinfusion in acute kidney injury secondary to angioimmunoblastic T-cell lymphoma: a case report. BLOOD PURIFICATION, 34(3-4), 349-353 [10.1159/000346288].
Staffolani, E; Nicolais, R; MANCA DI VILLAHERMOSA, S; Galli, D; Postorino, M; DI DANIELE, N
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/78038
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