Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. Phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Thus, a comprehensive picture of phosphatase function and the identification of their target substrates would aid a systematic approach to a mechanistic description of cell signalling. Here we present a website designed to facilitate the retrieval of information about human protein phosphatases. To this end we developed a search engine to recover and integrate information annotated in several publicly available web resources. In addition we present a text-mining-assisted annotation effort aimed at extracting phosphatase related data reported in the scientific literature. The HuPho (human phosphatases) website can be accessed at http://hupho.uniroma2.it.

Liberti, S., Sacco, F., Calderone, A., Perfetto, L., Iannuccelli, M., Panni, S., et al. (2013). HuPho: the human phosphatase portal. THE FEBS JOURNAL, 280(2), 379-387 [10.1111/j.1742-4658.2012.08712.x].

HuPho: the human phosphatase portal

Sacco, F;SANTONICO, ELENA;CASTAGNOLI, LUISA;CESARENI, GIOVANNI
2013-01-01

Abstract

Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. Phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Thus, a comprehensive picture of phosphatase function and the identification of their target substrates would aid a systematic approach to a mechanistic description of cell signalling. Here we present a website designed to facilitate the retrieval of information about human protein phosphatases. To this end we developed a search engine to recover and integrate information annotated in several publicly available web resources. In addition we present a text-mining-assisted annotation effort aimed at extracting phosphatase related data reported in the scientific literature. The HuPho (human phosphatases) website can be accessed at http://hupho.uniroma2.it.
2013
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/18 - GENETICA
English
Liberti, S., Sacco, F., Calderone, A., Perfetto, L., Iannuccelli, M., Panni, S., et al. (2013). HuPho: the human phosphatase portal. THE FEBS JOURNAL, 280(2), 379-387 [10.1111/j.1742-4658.2012.08712.x].
Liberti, S; Sacco, F; Calderone, A; Perfetto, L; Iannuccelli, M; Panni, S; Santonico, E; Palma, A; Nardozza, A; Castagnoli, L; Cesareni, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/77075
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