In recent years, the increase of migration from countries where human immunodeficiency virus type 2 (HIV-2) is endemic to industrialized countries has facilitated the spread of the virus in individuals previously unexposed to this threat. In this report, we performed a phylogenetic analysis on pol and env sequences of HIV-2 strains identified in foreigners and native citizens to trace the origin of infection. All but one of the 17 pol gene sequences were classified as group A. HIV-2 strains were aggregated in several clusters depending by the country of origin and/or infection. One patient (1AA) was classified as being infected with a recombinant between HIV-2 group A and HIV-2 group B, because the pol gene sequence was clearly in the group A, but an env V3 region sequence from this patient was more similar to group B viruses. Therefore, it is urgent to strengthen the surveillance and use adequate molecular virological tools to diagnose and monitor HIV-2 infection.
D'Ettorre, G., Lo Presti, A., Gori, C., Cella, E., Bertoli, A., Vullo, V., et al. (2013). An HIV Type 2 Case Series in Italy: A Phylogenetic Analysis. AIDS RESEARCH AND HUMAN RETROVIRUSES.
|Tipologia:||Articolo su rivista|
|Citazione:||D'Ettorre, G., Lo Presti, A., Gori, C., Cella, E., Bertoli, A., Vullo, V., et al. (2013). An HIV Type 2 Case Series in Italy: A Phylogenetic Analysis. AIDS RESEARCH AND HUMAN RETROVIRUSES.|
|Settore Scientifico Disciplinare:||Settore MED/07 - Microbiologia e Microbiologia Clinica|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1089/AID.2013.0091|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||25-mag-2013|
|Titolo:||An HIV Type 2 Case Series in Italy: A Phylogenetic Analysis|
|Autori:||D'Ettorre, G; Lo Presti, A; Gori, C; Cella, E; Bertoli, A; Vullo, V; Perno, CF; Ciotti, M; Foley, BT; Ciccozzi, M|
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