Microtubules are involved in cell growth and division, motility, signalling and in the development and maintenance of cell shape. Consequently, the non-equilibrium dynamics of these microtubules can be crucial to cellular function, including cancer development. Although the involvement of tubulins in human development has been well investigated, the role of alpha- and beta-tubulins in human tumorigenesis still remains controversial. The aim of this study was to investigate alpha- and beta-tubulin protein expression in rectal cancer development.
Giarnieri, E., De Francesco, G., Carico, E., Midiri, G., Amanti, C., Giacomelli, L., et al. (2005). Alpha- and beta-tubulin expression in rectal cancer development. ANTICANCER RESEARCH, 25(5), 3237-3241.
Alpha- and beta-tubulin expression in rectal cancer development
GIACOMELLI, LUIGI;TUCCI, GIANFRANCO;STROPPA, ITALO;
2005-01-01
Abstract
Microtubules are involved in cell growth and division, motility, signalling and in the development and maintenance of cell shape. Consequently, the non-equilibrium dynamics of these microtubules can be crucial to cellular function, including cancer development. Although the involvement of tubulins in human development has been well investigated, the role of alpha- and beta-tubulins in human tumorigenesis still remains controversial. The aim of this study was to investigate alpha- and beta-tubulin protein expression in rectal cancer development.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
