Nanotubes have a great therapeutic potential due to their astounding physico-chemical features, the possibility to be funtionalised for ad hoc uses, and the specific interaction of nanotubes as such with life molecules (DNA and proteins). These features recommend a thorough toxicological study before widespread pharmaceutic use. We provide evidence that culture cells with phagocytic potential internalise multi wall nanotubes (10-50 nm average size). This is not accompanied by cytotoxicity in terms of induction of &apoptosis or necrosis at the doses used (up to 125 microg/mI).
Ghibelli, L., DE NICOLA, M., Somma, G., Cerella, C., D'Alessio, M., Romeo, E., et al. (2005). [Lack of direct cytotoxic effect of intracellular nanotubes]. GIORNALE ITALIANO DI MEDICINA DEL LAVORO ED ERGONOMIA, 27(3), 383-384.
[Lack of direct cytotoxic effect of intracellular nanotubes]
GHIBELLI, LINA;DE NICOLA, MILENA;SOMMA, GIUSEPPINA;ROMEO, ELENA;MAGRINI, ANDREA;BERGAMASCHI, ANTONIO
2005-07-01
Abstract
Nanotubes have a great therapeutic potential due to their astounding physico-chemical features, the possibility to be funtionalised for ad hoc uses, and the specific interaction of nanotubes as such with life molecules (DNA and proteins). These features recommend a thorough toxicological study before widespread pharmaceutic use. We provide evidence that culture cells with phagocytic potential internalise multi wall nanotubes (10-50 nm average size). This is not accompanied by cytotoxicity in terms of induction of &apoptosis or necrosis at the doses used (up to 125 microg/mI).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
