Antioxidants-that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)-protect monocytic U937 cells from damage-induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress-induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiol\s oxidation and radical production.

Liuzzi, F., Fanelli, C., Ciriolo, M.r., Cerella, C., D'Alessio, M., Denicola, M., et al. (2003). Rescue of cells from apoptosis by antioxidants occurs downstream from GSH extrusion. In APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS [10.1196/annals.1299.080].

Rescue of cells from apoptosis by antioxidants occurs downstream from GSH extrusion

CIRIOLO, MARIA ROSA;MAGRINI, ANDREA;GHIBELLI, LINA
2003-01-01

Abstract

Antioxidants-that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)-protect monocytic U937 cells from damage-induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress-induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiol\s oxidation and radical production.
5th International Conference on Apoptosis from Signalling Pathways to Therapeutic Tools
LUXEMBOURG, LUXEMBOURG
JAN 29-FEB 01, 2003
Rilevanza internazionale
2003
Settore MED/44 - MEDICINA DEL LAVORO
English
Antioxidants; Apoptosis; Glutathione
2 oxobutyric acid; 2 oxoglutaric acid; 2 oxoisovaleric acid; antioxidant; dithiothreitol; glutathione; scavenger; thiol; apoptosis; cell culture; cell damage; cell protection; conference paper; controlled study; downstream processing; human; human cell; oxidative stress; protein expression; Anaerobiosis; Antioxidants; Apoptosis; Cell Hypoxia; Cell Survival; Glutathione; Humans; Puromycin; U937 Cells; Lethrinidae
Intervento a convegno
Liuzzi, F., Fanelli, C., Ciriolo, M.r., Cerella, C., D'Alessio, M., Denicola, M., et al. (2003). Rescue of cells from apoptosis by antioxidants occurs downstream from GSH extrusion. In APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS [10.1196/annals.1299.080].
Liuzzi, F; Fanelli, C; Ciriolo, Mr; Cerella, C; D'Alessio, M; Denicola, M; Magrini, A; Bergamaschi, A; Ghibelli, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/66142
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