Background: Radio-frequency ablation (RFA) has recently received much attention as an effective minimally invasive strategy for the local treatment of tumors. The purpose of this study was to evaluate the efficacy of single-needle cool-tip RF breast ablation in terms of temperature distribution and duration of the procedure as compared to multiprobe RF breast ablation. Materials and Methods: Two different commercially available radiofrequency ablation needle electrodes were compared. Finite-element method (FEM) models were developed to simulate the thermoablation procedures. A series of ex vivo radiofrequency thermal lesions were induced to check the response of the FEM calculations. Results: Data obtained from FEM models and from ex vivo procedures showed that cool-tip RF breast ablation assures better performances than multiprobe RF breast ablation in terms of temperature distribution and duration of the procedure. Histopathological analysis of the cool-tip RF thermoablated specimens showed successful induction of coagulation necrosis in the thermoablated specimens. Conclusion: Data obtained from FEM models and from ex vivo procedures suggest that the proposed cool-tip RF breast ablation may kill more tumor cells in vivo with a single application than the multiprobe RF breast ablation.

Quaranta, V., Manenti, G., Bolacchi, F., Cossu, E., Pistolese, C.a., Buonomo, O.c., et al. (2007). FEM analysis of RF breast ablation: Multiprobe versus cool-tip electrode. ANTICANCER RESEARCH, 27(2), 775-784.

FEM analysis of RF breast ablation: Multiprobe versus cool-tip electrode

MANENTI, GUGLIELMO;COSSU, ELSA;PISTOLESE, CHIARA ADRIANA;BUONOMO, ORESTE CLAUDIO;SIMONETTI, GIOVANNI MARIA EGISTO
2007-01-01

Abstract

Background: Radio-frequency ablation (RFA) has recently received much attention as an effective minimally invasive strategy for the local treatment of tumors. The purpose of this study was to evaluate the efficacy of single-needle cool-tip RF breast ablation in terms of temperature distribution and duration of the procedure as compared to multiprobe RF breast ablation. Materials and Methods: Two different commercially available radiofrequency ablation needle electrodes were compared. Finite-element method (FEM) models were developed to simulate the thermoablation procedures. A series of ex vivo radiofrequency thermal lesions were induced to check the response of the FEM calculations. Results: Data obtained from FEM models and from ex vivo procedures showed that cool-tip RF breast ablation assures better performances than multiprobe RF breast ablation in terms of temperature distribution and duration of the procedure. Histopathological analysis of the cool-tip RF thermoablated specimens showed successful induction of coagulation necrosis in the thermoablated specimens. Conclusion: Data obtained from FEM models and from ex vivo procedures suggest that the proposed cool-tip RF breast ablation may kill more tumor cells in vivo with a single application than the multiprobe RF breast ablation.
2007
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
English
Con Impact Factor ISI
Breast ablation; cool-tip electrode; FEM; finite-element method; multi-probe; RF ablation; RFA; animal tissue; article; breast surgery; controlled study; electrode; finite element analysis; histopathology; human; human tissue; intermethod comparison; nonhuman; priority journal; radiofrequency ablation; surgical technique; Animals; Body Temperature; Breast; Catheter Ablation; Cattle; Electrodes; Female; Humans; Liver; Mammary Glands, Animal
Quaranta, V., Manenti, G., Bolacchi, F., Cossu, E., Pistolese, C.a., Buonomo, O.c., et al. (2007). FEM analysis of RF breast ablation: Multiprobe versus cool-tip electrode. ANTICANCER RESEARCH, 27(2), 775-784.
Quaranta, V; Manenti, G; Bolacchi, F; Cossu, E; Pistolese, Ca; Buonomo, Oc; Carotenuto, L; Piconi, C; Simonetti, Gme
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/59928
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