To study the prevalence of early adversities in schizophrenia and unipolar depression, 2 groups of consecutive adult-onset inpatients with DSM-IV diagnoses of schizophrenia (n = 173) and unipolar depression (n = 305) were compared with an unscreened control group of volunteers from the general population (n = 310), with respect to their association with 4 types of childhood abuse and with early parental adversities (discord, separation, death, psychiatric caseness). Compared with general population, most types of early adversities (except sexual abuse and parental death) were significantly associated with both clinical groups. Compared with depression, all early adversities with the same 2 exceptions were significantly associated with schizophrenia; both frequency of abuse and number of types of abuse increased the risk of schizophrenia in a dose-response pattern, suggesting causality. These findings stress the role of social developmental factors in the etiology of schizophrenia.

Rubino, I., Nanni, R.c., Pozzi, D.m., Siracusano, A. (2009). Early adverse experiences in schizophrenia and unipolar depression. JOURNAL OF NERVOUS AND MENTAL DISEASE, 197(1), 65-68 [10.1097/NMD.0b013e3181925342].

Early adverse experiences in schizophrenia and unipolar depression

RUBINO, IVO;SIRACUSANO, ALBERTO
2009-01-01

Abstract

To study the prevalence of early adversities in schizophrenia and unipolar depression, 2 groups of consecutive adult-onset inpatients with DSM-IV diagnoses of schizophrenia (n = 173) and unipolar depression (n = 305) were compared with an unscreened control group of volunteers from the general population (n = 310), with respect to their association with 4 types of childhood abuse and with early parental adversities (discord, separation, death, psychiatric caseness). Compared with general population, most types of early adversities (except sexual abuse and parental death) were significantly associated with both clinical groups. Compared with depression, all early adversities with the same 2 exceptions were significantly associated with schizophrenia; both frequency of abuse and number of types of abuse increased the risk of schizophrenia in a dose-response pattern, suggesting causality. These findings stress the role of social developmental factors in the etiology of schizophrenia.
2009
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/25 - PSICHIATRIA
English
Child abuses; Depression; Early adversities; Schizophrenia
adult; article; causal attribution; child abuse; child sexual abuse; controlled study; death; diagnostic and statistical manual of mental disorders; divorce; family conflict; human; major clinical study; major depression; mental disease; mental patient; parental deprivation; schizophrenia; social evolution; bereavement; child; child development; depression; female; male; middle aged; onset age; parent; prevalence; psychological aspect; social change; Adult; Age of Onset; Bereavement; Child; Child Abuse; Child Abuse, Sexual; Child Development; Death; Depressive Disorder; Divorce; Family Conflict; Female; Humans; Male; Mental Disorders; Middle Aged; Parents; Prevalence; Schizophrenia; Social Change
Rubino, I., Nanni, R.c., Pozzi, D.m., Siracusano, A. (2009). Early adverse experiences in schizophrenia and unipolar depression. JOURNAL OF NERVOUS AND MENTAL DISEASE, 197(1), 65-68 [10.1097/NMD.0b013e3181925342].
Rubino, I; Nanni, Rc; Pozzi, Dm; Siracusano, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/58801
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