The metabolic syndrome is characterized by metabolic and cardiovascular disorders, including obesity, hypertension, impaired glucose tolerance and dyslipidemia. Recently, metabolic syndrome has been associated with a greater risk of atherosclerotic cardiovascular disease than any of its individual components. Its pathophysiology seems to be largely due to insulin resistance and visceral adiposity, leading to a proinflammatory and prothrombotic milieu that potentiates atherosclerosis. Recent knowledge implies a role for fat-derived "adipokines," as pathogenic contributors or protective factors. Furthermore, low plasma levels of ghrelin, an orexigenic peptide that promotes a positive energy balance, have been associated with the presence of vascular damage in patients with metabolic syndrome.

Iantorno, M., Tesauro, M., Cardillo, C. (2006). Recent acquisitions on the pathophysiology of metabolic syndrome [Recenti progressi nelle conoscenze della patogenesi della sindrome metabolica]. RECENTI PROGRESSI IN MEDICINA, 97(6), 303-307.

Recent acquisitions on the pathophysiology of metabolic syndrome [Recenti progressi nelle conoscenze della patogenesi della sindrome metabolica]

TESAURO, MANFREDI;
2006-01-01

Abstract

The metabolic syndrome is characterized by metabolic and cardiovascular disorders, including obesity, hypertension, impaired glucose tolerance and dyslipidemia. Recently, metabolic syndrome has been associated with a greater risk of atherosclerotic cardiovascular disease than any of its individual components. Its pathophysiology seems to be largely due to insulin resistance and visceral adiposity, leading to a proinflammatory and prothrombotic milieu that potentiates atherosclerosis. Recent knowledge implies a role for fat-derived "adipokines," as pathogenic contributors or protective factors. Furthermore, low plasma levels of ghrelin, an orexigenic peptide that promotes a positive energy balance, have been associated with the presence of vascular damage in patients with metabolic syndrome.
2006
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/09 - MEDICINA INTERNA
English
Senza Impact Factor ISI
adipocytokine; ghrelin; peroxisome proliferator activated receptor gamma; article; atherosclerosis; blood vessel injury; cardiovascular disease; disease association; dyslipidemia; impaired glucose tolerance; insulin resistance; metabolic syndrome X
Iantorno, M., Tesauro, M., Cardillo, C. (2006). Recent acquisitions on the pathophysiology of metabolic syndrome [Recenti progressi nelle conoscenze della patogenesi della sindrome metabolica]. RECENTI PROGRESSI IN MEDICINA, 97(6), 303-307.
Iantorno, M; Tesauro, M; Cardillo, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55884
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