Lymphocyte beta-adrenergic receptor function and norepinephrine (NE) plasma concentration have been compared in normal subjects and in ethanol-addicted patients of different ages. Direct measurement of the density and properties of beta-adrenoceptors in membrane fractions was performed using the radioligand 125I-Iodocyanopindolol (ICYP). In normal subjects beta-receptor density decreased and norepinephrine plasma concentration increased with age. There was a statistically significant negative correlation between plasma norepinephrine and beta-receptor number. In ethanol-addicted patients the age-related modification in beta-receptor number and the correlation between plasma norepinephrine and beta-receptor density were lost, in spite of the fact that the increase of NE plasma concentration was still present. The ethanol-induced effects in lymphocyte beta-receptor may have consequences on immunological function and may be qualitatively similar to alterations in other tissues not routinely accessible in humans.

Padovani, A., Govoni, S., Battaini, F.m., Magnoni, M., Civelli, L., Mauri, A., et al. (1987). Alcohol impairs age-dependent adaptation of human lymphocyte beta-adrenergic receptors. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 17(6), 511-514.

Alcohol impairs age-dependent adaptation of human lymphocyte beta-adrenergic receptors

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1987-12-01

Abstract

Lymphocyte beta-adrenergic receptor function and norepinephrine (NE) plasma concentration have been compared in normal subjects and in ethanol-addicted patients of different ages. Direct measurement of the density and properties of beta-adrenoceptors in membrane fractions was performed using the radioligand 125I-Iodocyanopindolol (ICYP). In normal subjects beta-receptor density decreased and norepinephrine plasma concentration increased with age. There was a statistically significant negative correlation between plasma norepinephrine and beta-receptor number. In ethanol-addicted patients the age-related modification in beta-receptor number and the correlation between plasma norepinephrine and beta-receptor density were lost, in spite of the fact that the increase of NE plasma concentration was still present. The ethanol-induced effects in lymphocyte beta-receptor may have consequences on immunological function and may be qualitatively similar to alterations in other tissues not routinely accessible in humans.
dic-1987
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Male; Age Factors; Middle Aged; Adaptation, Physiological; Norepinephrine; Aged; Adult; Receptors, Adrenergic, beta; Lymphocytes; Ethanol; Humans
Padovani, A., Govoni, S., Battaini, F.m., Magnoni, M., Civelli, L., Mauri, A., et al. (1987). Alcohol impairs age-dependent adaptation of human lymphocyte beta-adrenergic receptors. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 17(6), 511-514.
Padovani, A; Govoni, S; Battaini, Fm; Magnoni, M; Civelli, L; Mauri, A; Picotti, G; Galva, M; Trabucchi, Mm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55735
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