Literature data indicate a reduced calcium uptake in synaptosomes prepared from old rat brains. On this line, the present paper investigates the binding of ([3H]NDP) to brain synaptic membranes prepared from rats at different ages from birth up to 24 months of age. The binding is undetectable at birth but reaches within 9-18 day the values observed in adults [3H]NDP binding affinity and sensitivity to calcium were decreased in old rats (24 months). Tritiated dihydropyridines are believed to label voltage-dependent calcium channels (VDC). The observed age-related reduction in binding suggests that the characteristics of VDC in the aged brain may change.

Govoni, S., Rius, R., Battaini, F.m., Bianchi, A., Trabucchi, M.m. (1985). Age-related reduced affinity in [3H]nitrendipine labeling of brain voltage-dependent calcium channels. BRAIN RESEARCH, 333(2), 374-377.

Age-related reduced affinity in [3H]nitrendipine labeling of brain voltage-dependent calcium channels

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1985-05-06

Abstract

Literature data indicate a reduced calcium uptake in synaptosomes prepared from old rat brains. On this line, the present paper investigates the binding of ([3H]NDP) to brain synaptic membranes prepared from rats at different ages from birth up to 24 months of age. The binding is undetectable at birth but reaches within 9-18 day the values observed in adults [3H]NDP binding affinity and sensitivity to calcium were decreased in old rats (24 months). Tritiated dihydropyridines are believed to label voltage-dependent calcium channels (VDC). The observed age-related reduction in binding suggests that the characteristics of VDC in the aged brain may change.
6-mag-1985
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Ion Channels; Male; Age Factors; Nitrendipine; Nifedipine; Female; Rats, Inbred Strains; Rats; Animals; Calcium; Cerebral Cortex
Govoni, S., Rius, R., Battaini, F.m., Bianchi, A., Trabucchi, M.m. (1985). Age-related reduced affinity in [3H]nitrendipine labeling of brain voltage-dependent calcium channels. BRAIN RESEARCH, 333(2), 374-377.
Govoni, S; Rius, R; Battaini, Fm; Bianchi, A; Trabucchi, Mm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55679
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