Purpose: Sex-related influences have been implicated in the pathogenesis of vernal keratoconjunctivitis (VKC), an allergic eosinophilic disease. Methods: The authors evaluated tarsal and bulbar conjunctival biopsies from seven patients with severe and symptomatic VKC for the presence of estrogen and progesterone receptors by using monoclonal antibodies with a peroxidase-antiperoxidase technique. Results: Both the epithelium and subepithelium of the tarsal and bulbar conjunctiva of patients with VKC, but not those of four nonatopic control subjects, showed intense positive staining for estrogen and progesterone receptors. Immunofluorescence colocalization of both estrogen and progesterone receptors with eosinophil cationic protein showed that approximately 70% of positive cells were eosinophils. Conclusions: Sexual hormones, through their receptors, may influence the activity of eosinophils in patients with VKC.

Bonini, S., Lambiase, A., Schiavone, M., Centofanti, M., Palma, L., Bonini, S. (1995). ESTROGEN AND PROGESTERONE RECEPTORS IN VERNAL KERATOCONJUNCTIVITIS. OPHTHALMOLOGY, 102(9), 1374-1379.

ESTROGEN AND PROGESTERONE RECEPTORS IN VERNAL KERATOCONJUNCTIVITIS

CENTOFANTI, MARCO;
1995-01-01

Abstract

Purpose: Sex-related influences have been implicated in the pathogenesis of vernal keratoconjunctivitis (VKC), an allergic eosinophilic disease. Methods: The authors evaluated tarsal and bulbar conjunctival biopsies from seven patients with severe and symptomatic VKC for the presence of estrogen and progesterone receptors by using monoclonal antibodies with a peroxidase-antiperoxidase technique. Results: Both the epithelium and subepithelium of the tarsal and bulbar conjunctiva of patients with VKC, but not those of four nonatopic control subjects, showed intense positive staining for estrogen and progesterone receptors. Immunofluorescence colocalization of both estrogen and progesterone receptors with eosinophil cationic protein showed that approximately 70% of positive cells were eosinophils. Conclusions: Sexual hormones, through their receptors, may influence the activity of eosinophils in patients with VKC.
1995
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/30 - MALATTIE APPARATO VISIVO
English
Con Impact Factor ISI
MAJOR BASIC-PROTEIN; MAST-CELL; EOSINOPHIL; ESTRADIOL; UTERUS; ANTIBODIES; DEPOSITION
6
Bonini, S., Lambiase, A., Schiavone, M., Centofanti, M., Palma, L., Bonini, S. (1995). ESTROGEN AND PROGESTERONE RECEPTORS IN VERNAL KERATOCONJUNCTIVITIS. OPHTHALMOLOGY, 102(9), 1374-1379.
Bonini, S; Lambiase, A; Schiavone, M; Centofanti, M; Palma, L; Bonini, S
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/53057
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact