Objective: To evaluate cardiac function in structurally and chromosomally normal fetuses with increased nuchal translucency (NT). Methods: Forty-two structurally and chromosomally normal fetuses with increased NT at 11-14 weeks of gestation underwent fetal echocardiographic examination at 20-23 weeks. Fifty fetuses with normal NT values were considered as controls. Pulmonary and aortic peak velocity and time to peak velocities were measured as indices of ventricular systolic function. The ratios between the E-wave and A-wave (E/A) and the ratios between the E-wave and time velocity integral (E/TVI) at the level of both atrioventricular valves were evaluated as indices of ventricular diastolic function. Results: In fetuses with increased NT the E/A ratios were significantly decreased when compared to control fetuses at the level of both the mitral (0.52 ± 0.09 vs. 0.60 ± 0.10, P = 0.0002) and tricuspid (0.51 ± 0.09 vs. 0.61 ± 0.09, P < 0.0001) valves. Similar results were found for the E/TVI ratios (mitral valve 4.79 ± 1.03 vs. 5.63 ± 1.23, P = 0.0007 and tricuspid valve 4.40 ± 0.88 vs. 5.19 ± 0.82, P < 0.0001). No significant relationship was found between the degree of NT and the abnormalities in Doppler indices. There were no significant differences in Doppler systolic indices. Conclusion: Structurally and chromosomally normal fetuses with increased NT have low E/A and E/TVI ratios at 20-23 weeks of gestation. These findings might indicate cardiac diastolic dysfunction. Copyright © 2003 ISUOG. Published by John Wiley & Sons, Ltd.

Rizzo, G., Muscatello, A., Angelini, E., Capponi, A. (2003). Abnormal cardiac function in fetuses with increased nuchal translucency, 21(6), 539-542 [10.1002/uog.137].

Abnormal cardiac function in fetuses with increased nuchal translucency

RIZZO, GIUSEPPE;
2003-01-01

Abstract

Objective: To evaluate cardiac function in structurally and chromosomally normal fetuses with increased nuchal translucency (NT). Methods: Forty-two structurally and chromosomally normal fetuses with increased NT at 11-14 weeks of gestation underwent fetal echocardiographic examination at 20-23 weeks. Fifty fetuses with normal NT values were considered as controls. Pulmonary and aortic peak velocity and time to peak velocities were measured as indices of ventricular systolic function. The ratios between the E-wave and A-wave (E/A) and the ratios between the E-wave and time velocity integral (E/TVI) at the level of both atrioventricular valves were evaluated as indices of ventricular diastolic function. Results: In fetuses with increased NT the E/A ratios were significantly decreased when compared to control fetuses at the level of both the mitral (0.52 ± 0.09 vs. 0.60 ± 0.10, P = 0.0002) and tricuspid (0.51 ± 0.09 vs. 0.61 ± 0.09, P < 0.0001) valves. Similar results were found for the E/TVI ratios (mitral valve 4.79 ± 1.03 vs. 5.63 ± 1.23, P = 0.0007 and tricuspid valve 4.40 ± 0.88 vs. 5.19 ± 0.82, P < 0.0001). No significant relationship was found between the degree of NT and the abnormalities in Doppler indices. There were no significant differences in Doppler systolic indices. Conclusion: Structurally and chromosomally normal fetuses with increased NT have low E/A and E/TVI ratios at 20-23 weeks of gestation. These findings might indicate cardiac diastolic dysfunction. Copyright © 2003 ISUOG. Published by John Wiley & Sons, Ltd.
2003
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/40 - GINECOLOGIA E OSTETRICIA
English
Con Impact Factor ISI
Diastolic function; Fetal echocardiography; Fetal heart; Nuchal translucency
Rizzo, G., Muscatello, A., Angelini, E., Capponi, A. (2003). Abnormal cardiac function in fetuses with increased nuchal translucency, 21(6), 539-542 [10.1002/uog.137].
Rizzo, G; Muscatello, A; Angelini, E; Capponi, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51663
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