The in vivo and in vitro effect of oxiracetam, aniracetam and alpha-glicerylphosphorylcholine (alphaGPC) on protein kinase C (PKC) activity was studied in rat brain cortex and hippocampus. Administration of oxiracetam and alphaGPC in vivo elicited an early increase of particulate histone-directed PKC activity accompanied by a decrease of soluble activity and followed a few hours later by a down regulation of the enzyme. The effect was also observed in vitro when either oxiracetam or alphaGPC were administered at nanomolar concentrations to rat brain cortex slices. Aniracetam had no effect in the cortex but promoted PKC translocation both in vivo and in vitro in the hippocampus. In cortex slices the effect of oxiracetam was antagonized by the addition of AP-5, an NMDA receptor blocker, but not by CNQX and L-AP3, antagonists of AMPA and metabotropic glutamate receptors, respectively. Scopolamine also prevented the increase of particulate PKC elicited by oxiracetam in vitro. In the hippocampus the increase of particulate PKC activity was antagonized by AP-5, CNQX and L-AP3, indicating participation by both ionotropic and metabotropic glutamate receptors in the action of aniracetam. The data support the hypothesis that PKC activation may be a common mechanism amongst cognition stimulating drugs from different chemical classes.

Lucchi, L., Pascale, A., Battaini, F.m., Govoni, S., Trabucchi, M.m. (1993). COGNITION STIMULATING DRUGS MODULATE PROTEIN-KINASE-C ACTIVITY IN CEREBRAL-CORTEX AND HIPPOCAMPUS OF ADULT-RATS. LIFE SCIENCES, 53(24), 1821-1832.

COGNITION STIMULATING DRUGS MODULATE PROTEIN-KINASE-C ACTIVITY IN CEREBRAL-CORTEX AND HIPPOCAMPUS OF ADULT-RATS

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1993-01-01

Abstract

The in vivo and in vitro effect of oxiracetam, aniracetam and alpha-glicerylphosphorylcholine (alphaGPC) on protein kinase C (PKC) activity was studied in rat brain cortex and hippocampus. Administration of oxiracetam and alphaGPC in vivo elicited an early increase of particulate histone-directed PKC activity accompanied by a decrease of soluble activity and followed a few hours later by a down regulation of the enzyme. The effect was also observed in vitro when either oxiracetam or alphaGPC were administered at nanomolar concentrations to rat brain cortex slices. Aniracetam had no effect in the cortex but promoted PKC translocation both in vivo and in vitro in the hippocampus. In cortex slices the effect of oxiracetam was antagonized by the addition of AP-5, an NMDA receptor blocker, but not by CNQX and L-AP3, antagonists of AMPA and metabotropic glutamate receptors, respectively. Scopolamine also prevented the increase of particulate PKC elicited by oxiracetam in vitro. In the hippocampus the increase of particulate PKC activity was antagonized by AP-5, CNQX and L-AP3, indicating participation by both ionotropic and metabotropic glutamate receptors in the action of aniracetam. The data support the hypothesis that PKC activation may be a common mechanism amongst cognition stimulating drugs from different chemical classes.
1993
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
LONG-TERM POTENTIATION; AMINO-ACID RECEPTORS; D-ASPARTATE RECEPTOR; BRAIN ACETYLCHOLINE; MEMORY; OXIRACETAM; ANIRACETAM; BINDING; TRANSLOCATION; PERFORMANCE
12
Lucchi, L., Pascale, A., Battaini, F.m., Govoni, S., Trabucchi, M.m. (1993). COGNITION STIMULATING DRUGS MODULATE PROTEIN-KINASE-C ACTIVITY IN CEREBRAL-CORTEX AND HIPPOCAMPUS OF ADULT-RATS. LIFE SCIENCES, 53(24), 1821-1832.
Lucchi, L; Pascale, A; Battaini, Fm; Govoni, S; Trabucchi, Mm
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51572
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact