The aim of the present review is to discuss recent acquisitions on the neurophysiological effects of the DA denervation of the striatum, obtained in vitro from single neurone electrophysiological recordings. Nigrostriatal DA system degeneration does not significantly alter the intrinsic properties of striatal cells, but triggers adaptive responses in the striatum, involving glutamatergic neurotransmission. By pairing intracellular recordings from 6-OHDA-denervated striatal projection neurones and the synaptic stimulation of glutamatergic corticostriatal pathway, in vitro experiments contributed to elucidate the intimate alterations that follow striatal DA deafferentation. This experimental approach also allowed to better understand the possible cellular bases of both beneficial and side effects of the pharmacological compounds commonly employed in the treatment of PD.

Centonze, D., Calabresi, P., Giacomini, P., Bernardi, G. (1999). Neurophysiology of Parkinson's disease: from basic research to clinical correlates. CLINICAL NEUROPHYSIOLOGY, 110(12), 2006-2013 [10.1016/S1388-2457(99)00173-X].

Neurophysiology of Parkinson's disease: from basic research to clinical correlates

CENTONZE, DIEGO;CALABRESI, PAOLO;BERNARDI, GIORGIO
1999-12-01

Abstract

The aim of the present review is to discuss recent acquisitions on the neurophysiological effects of the DA denervation of the striatum, obtained in vitro from single neurone electrophysiological recordings. Nigrostriatal DA system degeneration does not significantly alter the intrinsic properties of striatal cells, but triggers adaptive responses in the striatum, involving glutamatergic neurotransmission. By pairing intracellular recordings from 6-OHDA-denervated striatal projection neurones and the synaptic stimulation of glutamatergic corticostriatal pathway, in vitro experiments contributed to elucidate the intimate alterations that follow striatal DA deafferentation. This experimental approach also allowed to better understand the possible cellular bases of both beneficial and side effects of the pharmacological compounds commonly employed in the treatment of PD.
dic-1999
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
Electrophysiology; Parkinson Disease; Brain; Humans
Centonze, D., Calabresi, P., Giacomini, P., Bernardi, G. (1999). Neurophysiology of Parkinson's disease: from basic research to clinical correlates. CLINICAL NEUROPHYSIOLOGY, 110(12), 2006-2013 [10.1016/S1388-2457(99)00173-X].
Centonze, D; Calabresi, P; Giacomini, P; Bernardi, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51496
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