Depolarizing stimuli increase the release of neurotransmitter met-enkephalin from rat striatal slices. Bay K8644, a calcium agonist, significantly enhances the submaximal release of this peptide. Several organic calcium antagonists, including nimodipine, nifedipine, nicardipine, gallopamil and flunarizine, are able to inhibit the potassium-evoked met-enkephalin release both in vitro and ex vivo. The data suggest that the release of this neuropeptide is modulated by calcium antagonist-sensitive calcium channels.
Govoni, S., Goss, I., Di Giovine, S., Battaini, F.m., Trabucchi, M.m. (1990). Calcium antagonists inhibit met-enkephalin immunoreactive material release: in vitro and ex vivo experiments. JOURNAL OF NEURAL TRANSMISSION, 80(1), 1-8.
Calcium antagonists inhibit met-enkephalin immunoreactive material release: in vitro and ex vivo experiments
BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1990-01-01
Abstract
Depolarizing stimuli increase the release of neurotransmitter met-enkephalin from rat striatal slices. Bay K8644, a calcium agonist, significantly enhances the submaximal release of this peptide. Several organic calcium antagonists, including nimodipine, nifedipine, nicardipine, gallopamil and flunarizine, are able to inhibit the potassium-evoked met-enkephalin release both in vitro and ex vivo. The data suggest that the release of this neuropeptide is modulated by calcium antagonist-sensitive calcium channels.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
