The effects of different in vivo thymosin alpha one (T-alpha-1) treatments on T-cell responses inhibited by cocaine abuse were studied. Administration during cocaine treatment promoted a faster recovery of normal natural killer (NK) cell activity after the suspension of abuse. Suspension of cocaine plus repeated T-alpha-1 administrations strongly restored NK activity and, interestingly, spleen cells from mice treated with T-alpha-1 during and after cocaine administration achieved a very rapid recovery and the greatest stimulation of natural cytotoxicity. This last treatment also restored the cocaine-inhibited specific T-cell response (i.e. allogeneic cytotoxic T-lymphocyte (CTL) generation) and abrograted the cocaine-induced suppression of interferon gamma (IFN-gamma), interleukin 2 (IL-2) and IL-4 production. Finally restoration and induction of thymic cellularity were significant when T-alpha-1 was given during and after cocaine administration. The present investigation provides evidence for the first time that thymic hormones could be of potential value in controlling cocaine-induced impairment of T-cell-mediated immunity in the mouse.

Difrancesco, P., Pica, F., Marini, S., Favalli, C., Garaci, E. (1992). THYMOSIN ALPHA-1 RESTORES MURINE T-CELL-MEDIATED RESPONSES INHIBITED BY INVIVO COCAINE ADMINISTRATION. INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 14(1), 1-9.

THYMOSIN ALPHA-1 RESTORES MURINE T-CELL-MEDIATED RESPONSES INHIBITED BY INVIVO COCAINE ADMINISTRATION

PICA, FRANCESCA;MARINI, STEFANO;FAVALLI, CARTESIO;GARACI, ENRICO
1992-01-01

Abstract

The effects of different in vivo thymosin alpha one (T-alpha-1) treatments on T-cell responses inhibited by cocaine abuse were studied. Administration during cocaine treatment promoted a faster recovery of normal natural killer (NK) cell activity after the suspension of abuse. Suspension of cocaine plus repeated T-alpha-1 administrations strongly restored NK activity and, interestingly, spleen cells from mice treated with T-alpha-1 during and after cocaine administration achieved a very rapid recovery and the greatest stimulation of natural cytotoxicity. This last treatment also restored the cocaine-inhibited specific T-cell response (i.e. allogeneic cytotoxic T-lymphocyte (CTL) generation) and abrograted the cocaine-induced suppression of interferon gamma (IFN-gamma), interleukin 2 (IL-2) and IL-4 production. Finally restoration and induction of thymic cellularity were significant when T-alpha-1 was given during and after cocaine administration. The present investigation provides evidence for the first time that thymic hormones could be of potential value in controlling cocaine-induced impairment of T-cell-mediated immunity in the mouse.
1992
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
NATURAL-KILLER CELLS; INTERLEUKIN-2 RECEPTOR EXPRESSION; NORMAL HUMAN-LYMPHOCYTES; MICE; MODULATION; INTERFERON; AUGMENTATION; PRECURSORS; THYMUS
9
Difrancesco, P., Pica, F., Marini, S., Favalli, C., Garaci, E. (1992). THYMOSIN ALPHA-1 RESTORES MURINE T-CELL-MEDIATED RESPONSES INHIBITED BY INVIVO COCAINE ADMINISTRATION. INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 14(1), 1-9.
Difrancesco, P; Pica, F; Marini, S; Favalli, C; Garaci, E
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/50866
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 17
  • ???jsp.display-item.citation.isi??? 14
social impact