The G(0)/G(1) to S-phase transition in quiescent EL2 rat fibroblast cells stimulated by mitogen (such as the epidermal growth factor) can be blocked by the addition of morphine to the system. The drug must be actively present when quiescent EL2 cells are induced to enter the proliferative slate. Even when morphine is added after mitogenic stimulus, an exposure only within 6 hours is required to inhibit DNA synthesis. These results suggest that morphine can directly influence the proliferation of the nonlymphoid cell system, particularly during the establishment oi a competence state (i.e., G(0)/S phase transition).
Difrancesco, P., Gaziano, R., Casalinuovo, I.a., Palamara, A., Favalli, C. (1994). INHIBITORY EFFECT OF MORPHINE ON THE CONTROL OF RAT FIBROBLAST CELL-PROLIFERATION. INTERNATIONAL JOURNAL OF TISSUE REACTIONS, 16(2009/06/05 00:00:00.000), 205-210.
INHIBITORY EFFECT OF MORPHINE ON THE CONTROL OF RAT FIBROBLAST CELL-PROLIFERATION
GAZIANO, ROBERTA;CASALINUOVO, IDA ANTONIA;FAVALLI, CARTESIO
1994-01-01
Abstract
The G(0)/G(1) to S-phase transition in quiescent EL2 rat fibroblast cells stimulated by mitogen (such as the epidermal growth factor) can be blocked by the addition of morphine to the system. The drug must be actively present when quiescent EL2 cells are induced to enter the proliferative slate. Even when morphine is added after mitogenic stimulus, an exposure only within 6 hours is required to inhibit DNA synthesis. These results suggest that morphine can directly influence the proliferation of the nonlymphoid cell system, particularly during the establishment oi a competence state (i.e., G(0)/S phase transition).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
