To clarify the possible relationship between fragile site expression and cancer, we examined lymphocytes from patients affected by neuroblastoma. This neoplasia may be inherited in some cases and is often characterized by a specific chromosomal aberration: deletion of the short arm of chromosome 1. We found a higher expression of fragile sites after aphidicolin and, to a lesser extent, after methotrexate treatment in lymphocytes from neuroblastoma patients as compared with those of normal donors. The analysis of fragile site distribution pointed out the increase in the expression of fragile site 1p32 in the patients. We believe that this finding might be relevant because this fragile site is located in the same region where breakpoints and rearrangements frequently occur in neuroblastoma cells.

Vernole, P., Tedeschi, B., Caporossi, D., Nicoletti, B. (1988). Common fragile sites and human cancer. A study on lymphocytes from neuroblastoma patients. CANCER GENETICS AND CYTOGENETICS, 36(1), 13-23.

Common fragile sites and human cancer. A study on lymphocytes from neuroblastoma patients

VERNOLE, PATRIZIA;
1988-11-01

Abstract

To clarify the possible relationship between fragile site expression and cancer, we examined lymphocytes from patients affected by neuroblastoma. This neoplasia may be inherited in some cases and is often characterized by a specific chromosomal aberration: deletion of the short arm of chromosome 1. We found a higher expression of fragile sites after aphidicolin and, to a lesser extent, after methotrexate treatment in lymphocytes from neuroblastoma patients as compared with those of normal donors. The analysis of fragile site distribution pointed out the increase in the expression of fragile site 1p32 in the patients. We believe that this finding might be relevant because this fragile site is located in the same region where breakpoints and rearrangements frequently occur in neuroblastoma cells.
nov-1988
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/13 - BIOLOGIA APPLICATA
English
Con Impact Factor ISI
Male; Adolescent; Cells, Cultured; Female; Chromosomes, Human, Pair 1; Aphidicolin; Methotrexate; Neuroblastoma; Humans; Chromosome Fragility; Chromosome Fragile Sites; Child; Diterpenes; Adult; Lymphocytes; Bone Marrow
Vernole, P., Tedeschi, B., Caporossi, D., Nicoletti, B. (1988). Common fragile sites and human cancer. A study on lymphocytes from neuroblastoma patients. CANCER GENETICS AND CYTOGENETICS, 36(1), 13-23.
Vernole, P; Tedeschi, B; Caporossi, D; Nicoletti, B
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/50276
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