Objective and Design: to assess if deletion of the angiotensin-converting enzyme (ACE) gene is a risk factor for abdominal aortic aneurysms (AAAs) in normotensive patients. Materials and Methods: ACE gene polymorphism was examined by polymerase chain reaction in 124 subjects with AAA and in 112 control subjects. AAA normotensive patients (group A, n=56) were compared to normotensive control subjects (group B, n=112) and to AAA hypertensive patients (group C, n=68). All subjects enrolled in this study were Caucasian and from central and southern Italy. Results: the distribution of ACE genotypes was: normotensive patients with AAAs (group A): 3 II, 24 ID, 39 DD; normotensive control subjects (group B): 36 II, 48 ID, 28 DD; hypertensive patients with AAAs (group C): 14 II, 32 ID, 22 DD. The DD genotype was more common in group A than in control groups (A vs B: p <0.001; A vs C: p <0.001). The ID genotype was move common in group A as well (A vs B: p <0.05; A vs C: p <0.005). Conclusions: our data suggest a role for ACE I/D gene polymorphism in the pathogenesis of AAA in normotensive patients.

Pola, R., Gaetani, E., Santoliquido, A., Gerardino, L., Cattani, P., Serricchio, M., et al. (2001). Abdominal aortic aneurysm in normotensive patients: Association with angiotensin-converting enzyme gene polymorphism. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 21(5), 445-449 [10.1053/ejvs.2001.1339].

Abdominal aortic aneurysm in normotensive patients: Association with angiotensin-converting enzyme gene polymorphism

GRANDE, MICHELE;
2001-01-01

Abstract

Objective and Design: to assess if deletion of the angiotensin-converting enzyme (ACE) gene is a risk factor for abdominal aortic aneurysms (AAAs) in normotensive patients. Materials and Methods: ACE gene polymorphism was examined by polymerase chain reaction in 124 subjects with AAA and in 112 control subjects. AAA normotensive patients (group A, n=56) were compared to normotensive control subjects (group B, n=112) and to AAA hypertensive patients (group C, n=68). All subjects enrolled in this study were Caucasian and from central and southern Italy. Results: the distribution of ACE genotypes was: normotensive patients with AAAs (group A): 3 II, 24 ID, 39 DD; normotensive control subjects (group B): 36 II, 48 ID, 28 DD; hypertensive patients with AAAs (group C): 14 II, 32 ID, 22 DD. The DD genotype was more common in group A than in control groups (A vs B: p <0.001; A vs C: p <0.001). The ID genotype was move common in group A as well (A vs B: p <0.05; A vs C: p <0.005). Conclusions: our data suggest a role for ACE I/D gene polymorphism in the pathogenesis of AAA in normotensive patients.
2001
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/22 - CHIRURGIA VASCOLARE
English
INSERTION DELETION POLYMORPHISM; ARTERIAL-WALL THICKNESS; ESSENTIAL-HYPERTENSION; SCREENING-PROGRAM; I/D POLYMORPHISM; ITALIAN PATIENTS; RISK-FACTORS; ATHEROSCLEROSIS; HYPERTROPHY; INFARCTION
5
Pola, R., Gaetani, E., Santoliquido, A., Gerardino, L., Cattani, P., Serricchio, M., et al. (2001). Abdominal aortic aneurysm in normotensive patients: Association with angiotensin-converting enzyme gene polymorphism. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 21(5), 445-449 [10.1053/ejvs.2001.1339].
Pola, R; Gaetani, E; Santoliquido, A; Gerardino, L; Cattani, P; Serricchio, M; Tondi, P; Flore, R; Grande, M; Carbonin, P; Fadda, G; Pola, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/50111
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